Found 1 structure.
Displayed structure 1
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1. Compound ID: 19623
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a-D-Manp-(1-6)-+
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a-D-Manp-(1-2)-a-D-Manp-(1-3)-+
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a-D-Manp-(1-3)-+ |
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{{{-D-Galf-(1-?)-}}}/n=0-1/-a-D-Manp-(1-2)-{{{-a-D-Manp-(1-2)-}}}/n=0-6/-a-D-Manp-(1-6)-a-D-Manp-(1-6)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-b-D-GlcNAc |
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Structure type: structural motif or average structure
; 1257 (Hex5HexNAc2), 1419 (Hex6HexNAc2), 1581 (Hex7HexNAc2), 1743 (Hex8HexNAc2), 1905 (Hex9HexNAc2), 2067 (Hex10HexNAc2), 2229 (Hex11HexNAc2)
Compound class: N-glycan, galactomannan
Contained glycoepitopes: IEDB_123886,IEDB_130701,IEDB_135813,IEDB_136095,IEDB_136104,IEDB_137340,IEDB_137472,IEDB_137485,IEDB_140116,IEDB_141793,IEDB_141795,IEDB_141807,IEDB_141828,IEDB_141829,IEDB_141830,IEDB_141831,IEDB_141832,IEDB_141833,IEDB_141834,IEDB_143632,IEDB_144983,IEDB_147453,IEDB_149137,IEDB_149176,IEDB_151079,IEDB_151531,IEDB_152206,IEDB_153212,IEDB_153220,IEDB_164174,IEDB_164480,IEDB_187201,IEDB_190606,IEDB_423157,IEDB_429156,IEDB_548907,IEDB_76933,IEDB_857734,IEDB_885812,IEDB_983930,SB_136,SB_191,SB_196,SB_197,SB_198,SB_33,SB_44,SB_53,SB_67,SB_72,SB_73,SB_74,SB_77,SB_85
The structure is contained in the following publication(s):
- Article ID: 7733
Morelle W, Bernard M, Debeaupuis JP, Buitrago M, Tabouret M, Latge JP "Galactomannoproteins of Aspergillus fumigatus" -
Eukaryotic Cell 4(7) (2005) 1308-1316
Galactofuranose-containing molecules have been repeatedly shown to be important antigens among human fungal pathogens, including Aspergillus fumigatus. Immunogenic galactofuran determinants have been poorly characterized chemically, however. We reported here the characterization of two glycoproteins of A. fumigatus with an N-glycan containing galactofuranose. These proteins are a phospholipase C and a phytase. Chemical characterization of the N-glycan indicates that it is a mixture of Hex(5-13)HexNAc(2) oligosaccharides, the major molecular species corresponding to Hex(6-8)HexNAc(2). The N-glycan contained one galactofuranose unit that was in a terminal nonreducing position attached to the 2 position of Man. This single terminal nonreducing galactofuranose is essential for the immunoreactivity of the N-glycans assessed either with a monoclonal antibody that recognizes a tetra-β-1,5-galactofuran chain of galactomannan or with Aspergillus-infected patient sera.
NCBI PubMed ID: 16002656Publication DOI: 10.1128/EC.4.7.1308-1316.2005Journal NLM ID: 101130731Publisher: American Society for Microbiology
Correspondence: jplatge@pasteur.fr
Institutions: Unité des Aspergillus, Institut Pasteur, Paris, France, Bio-Rad, Clinical Microbiology Division, Steenvoorde, France
Methods: GC-MS, GLC, methylation analysis, TFA hydrolysis, MALD-MS
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