Show legend Show as text

Structure type: monomer
C₃₄H₅₈O₁₀
Compound class: glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 7766
  Bok JW, Lermer L, Chilton J, Klingeman HG, Towers GH "Antitumor sterols from the mycelia of Cordyceps sinensis" - Phytochemistry 51(7) (1999) 891-898
  

  Activity guided fractionations led to the isolation of two antitumor compounds 5a,8a-epidioxy-24(R)-methylcholesta-6,22-dien-3β-D-glucopyranoside and 5,6-epoxy-24(R)-methylcholesta-7,22-dien-3β-ol from the methanol extract of Cordyceps sinensis. Two previously known compounds, ergosteryl-3-O-β-D-glucopyranoside and 22-dihydroergosteryl-3-O-β-D-glucopyranoside were also isolated. The structures of hitherto unknown sterols were established by 1D and 2D NMR spectroscopic techniques with the former synthesized in order to confirm the identity of the sugar moiety by chemical correlation. The glycosylated form of ergosterol peroxide was found to be a greater inhibitor to the proliferation of K562, Jurkat, WM-1341, HL-60 and RPMI-8226 tumor cell lines by 10 to 40% at 10 mg/ml than its previously identified aglycone, 5a,8a-epidioxy-24(R)-methylcholesta-6,22-dien-3β-ol

  antitumor activity, Cordyceps sinensis, steroidal glycosides, Cordyceps sinenis

  NCBI PubMed ID: 10423860
  Publication DOI: 10.1016/s0031-9422(99)00128-4
  Journal NLM ID: 0151434
  Publisher: Elsevier
  Institutions: Department of Botany, University of British Columbia, Vancouver, Canada, North American Reishi, Gibsons, British Columbia, Canada, Department of Medicine, Terry Fox Laboratory, University of British Columbia, Vancouver, Canada, North American Reishi, Gibsons, Canada
  Methods: 13C NMR, 1H NMR, NMR-2D, IR, TLC, ESI-MS, FTIR, extraction, optical rotation measurement, CC, HMBC, antitumor activity assay, HMQC, APT, HRMS
  
   
  
  Cordyceps sinensis
  CSDB ID 46037 (all data & tools)
• Article ID: 8423
  Liu Y, Wang J, Wang W, Zhang H, Zhang X, Han C "The chemical constituents and pharmacological actions of Cordyceps sinensis" - Evidence-based Complementary and Alternative Medicine 2015 (2015) ID 575063
  

  Cordyceps sinensis, also called DongChongXiaCao (winter worm, summer grass) in Chinese, is becoming increasingly popular and important in the public and scientific communities. This study summarizes the chemical constituents and their corresponding pharmacological actions of Cordyceps sinensis. Many bioactive components of Cordyceps sinensis have been extracted including nucleoside, polysaccharide, sterol, protein, amino acid, and polypeptide. In addition, these constituents’ corresponding pharmacological actions were also shown in the study such as anti-inflammatory, antioxidant, antitumour, antiapoptosis, and immunomodulatory actions. Therefore can use different effects of C. sinensis against different diseases and provide reference for the study of Cordyceps sinensis in the future

  polysaccharides, Cordyceps sinensis, nucleosides, sterol compounds

  NCBI PubMed ID: 25960753
  Publication DOI: 10.1155/2015/575063
  Journal NLM ID: 101215021
  Publisher: New York, NY: Hindawi Pub
  Correspondence: Han C
  Institutions: School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China, Teaching Experiment Center, Shandong University of Traditional Chinese Medicine, Jinan, China, College of Acumox and Tuina, Shandong University of Traditional Chinese Medicine, Jinan, China
  
   
  
  Cordyceps sinensis
  CSDB ID 48386 (all data & tools)

Show legend Show as text

Structure type: monomer ; 608.41572 [M+NH4]+
C₃₄H₅₄O₈
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 7766
  Bok JW, Lermer L, Chilton J, Klingeman HG, Towers GH "Antitumor sterols from the mycelia of Cordyceps sinensis" - Phytochemistry 51(7) (1999) 891-898
  

  Activity guided fractionations led to the isolation of two antitumor compounds 5a,8a-epidioxy-24(R)-methylcholesta-6,22-dien-3β-D-glucopyranoside and 5,6-epoxy-24(R)-methylcholesta-7,22-dien-3β-ol from the methanol extract of Cordyceps sinensis. Two previously known compounds, ergosteryl-3-O-β-D-glucopyranoside and 22-dihydroergosteryl-3-O-β-D-glucopyranoside were also isolated. The structures of hitherto unknown sterols were established by 1D and 2D NMR spectroscopic techniques with the former synthesized in order to confirm the identity of the sugar moiety by chemical correlation. The glycosylated form of ergosterol peroxide was found to be a greater inhibitor to the proliferation of K562, Jurkat, WM-1341, HL-60 and RPMI-8226 tumor cell lines by 10 to 40% at 10 mg/ml than its previously identified aglycone, 5a,8a-epidioxy-24(R)-methylcholesta-6,22-dien-3β-ol

  antitumor activity, Cordyceps sinensis, steroidal glycosides, Cordyceps sinenis

  NCBI PubMed ID: 10423860
  Publication DOI: 10.1016/s0031-9422(99)00128-4
  Journal NLM ID: 0151434
  Publisher: Elsevier
  Institutions: Department of Botany, University of British Columbia, Vancouver, Canada, North American Reishi, Gibsons, British Columbia, Canada, Department of Medicine, Terry Fox Laboratory, University of British Columbia, Vancouver, Canada, North American Reishi, Gibsons, Canada
  Methods: 13C NMR, 1H NMR, NMR-2D, IR, TLC, ESI-MS, FTIR, extraction, optical rotation measurement, CC, HMBC, antitumor activity assay, HMQC, APT, HRMS
  
   
  
  Cordyceps sinensis
  CSDB ID 46662 (all data & tools)