Two new compounds, paecilospirone (1) and phomopsidin (2), and seven known compounds, chaetoglobosin A (3), griseofulvin (4), fusarielin A (5), fusapyrone (6), deoxyfusapyrone (7), and verrucarins J (8) and L acetate (9), have been isolated and characterized from marine-derived fungi collected in tropical and sub-tropical coral reef environments. The utility of marine-derived fungi as a source of bioactive secondary metabolites is discussed.
isolation, Marine fungi, bioactive metabolite, paecilospirone, phomopsidin, marine natural product
NCBI PubMed ID: 11045449Publication DOI: 10.1248/cpb.48.1452Journal NLM ID: 0377775Publisher: Pharmaceutical Society Of Japan
Correspondence: namikosh@tokyo-u-fish.ac.jp
Institutions: Department of Ocean Sciences, Tokyo University of Fisheries, Tokyo, Japan, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
Methods: 13C NMR, 1H NMR, IR, TLC, ESI-MS, biological assays, HPLC, UV, optical rotation measurement, CC, cell growth, cytotoxicity assay, evaporation, HR-FAB-MS