Although Pleurotus abalonus is a well-known edible mushroom in Asia, there is a dearth of information on its antioxidant activity. The present report is the first one focused on the purification and characterization of 9-β-D-ribofuranosidoadenine (ADO), 5'-deoxy-5'-(methylthio) adenosine (MTA) and a triterpenoid complex from P. abalonus. Different antioxidant activities including inhibitory effects on hemolysis and lipid peroxidation in brain and kidney homogenates as well as significant synergistic effect on scavenging of hydroxyl radicals were demonstrated, which lays a foundation for the development of P. abalonus as a natural antioxidant applied in medicine.
Antioxidant, Pleurotus abalonus, triterpenoid, 9-β-D-ribofuranosidoadenine, 5′-deoxy-5′-(methylthio) adenosine
NCBI PubMed ID: 23892470Publication DOI: 10.1016/j.etap.2013.06.007Journal NLM ID: 9612020Publisher: Amsterdam: Elsevier
Correspondence: Ng TB
; Liu F
Institutions: Department of Microbiology, Nankai University, Tianjin, China, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China, Tianjin Hospital, Tianjin, China
Methods: TLC, HPLC, ion-exchange chromatography, extraction, LC-MS, HPGPC, biological assay, radical scavenging assay
Found