Colleflaccinosides A and B, two chiral bianthraquinone glycosides from the two geographical varieties of lichen Collema flaccidum collected in Russia and Israel have been isolated as new natural products. Their structures were elucidated using UV, CD, IR, MS, 1D and 2D NMR spectral data, and chemical degradation. The colleflaccinosides B had significant antitumor activity in the crown gall tumor inhibition test.
Russia, antitumor activity, Collema flaccidum, jelly lichen, Israel, Bianthraquinone glycosides, colleflaccinosides A and B, facility mayak
NCBI PubMed ID: 16854728Publication DOI: 10.1080/14786410500218674Journal NLM ID: 101167924Publisher: Milton Park, UK : Taylor & Francis Health Sciences
Correspondence: Rezanka T
Institutions: Department of Organic Chemistry, Hebrew University of Jerusalem, Jerusalem, Israel, Institute of Microbiology, Prague, Czech Republic
Methods: 13C NMR, 1H NMR, gel filtration, NMR-2D, IR, FAB-MS, GC-MS, TLC, acid hydrolysis, GC, HPLC, UV, extraction, optical rotation measurement, CD, enzymatic assay, biological assay, antitumor activity assay, HR-FAB-MS, LR-FAB-MS