Taxonomic group: bacteria / Deinococcus-Thermus
(Phylum: Deinococcus-Thermus)
The structure was elucidated in this paperNCBI PubMed ID: 16636007Journal NLM ID: 9104124Publisher: IRL Press at Oxford University Press
Institutions: Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli Federico II, Via Cintia 4, I-80126 Napoli, Italy, Division of Structural Biochemistry, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, D-23845 Borstel, Germany
Thermophiles constitute a class of microrganisms able to grow at extremely elevated temperatures. Some of these species are classified as Gram-negative bacteria, due to the presence of an outer membrane in the cell envelope, which is located on the top of a thick murein layer. Unlike typical Gram-negative bacteria, the outer membranes of Thermus species are not composed by lipopolysaccharides but by peculiar glycolipids, whose structures seem to be strictly involved in the adaptation to high temperatures. In the present work, the complete structures of the major glycolipid components from the cell envelope of the thermophilic bacterium Thermus thermophilus Samu-SA1 are presented. Protocols conventionally adopted for Gram-negative bacteria were used, and, for the first time, glycolipids from Thermus were analysed in their native form. Two glycolipids and one phosphoglycolipid were detected and characterised. The two glycolipids, analysed by NMR spectroscopy and ESI FT-ICR mass spectrometry, possessed the same tetrasaccharide structure linked to a glycerol unit or, alternatively, to a long-chain diol. Moreover, a phosphoglycolipid from Thermus was characterised for the first time, in which N-glyceroyl-heptadecaneamine was present. These molecules are chemically related to other glycolipids from thermophile bacteria, in which they play a crucial role in the adaptation of cell membranes to heat
NMR, glycolipid, ESI FT-MS, long-chain diol, Thermus thermophilus
Structure type: oligomer
Location inside paper: p.771
Aglycon: NH(CH2)16CH3
Compound class: glycophospholipid, PGL
Contained glycoepitopes: IEDB_130695,IEDB_141807,IEDB_151531
Methods: NMR, MS
Related record ID(s): 20119, 20416, 20417
NCBI Taxonomy refs (TaxIDs): 274
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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