A new phenolic glucoside, acremonoside (1), along with two known compounds, F-11334 A2 and 2,2-dimethyl-2H-chromen-6-ol, were isolated from the sea fan-derived fungus Acremonium polychromum PSU-F125. The structure of 1 was elucidated by spectroscopic techniques, acid hydrolysis and X-ray crystallographic analysis. The isolated compounds were tested for antibacterial, antimalarial, antimycobacterial and cytotoxic activities.
Acremonium polychromum, phenolic glucoside, sea fan-derived fungus
Publication DOI: 10.1016/j.phytol.2014.08.002Journal NLM ID: 101513432Publisher: Amsterdam: Elsevier
Correspondence: Rukachaisirikul V
Institutions: National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani, Thailand, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand, Department of Microbiology and Natural Products Research Center of Excellence, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand
Methods: 13C NMR, 1H NMR, X-ray, TLC, UV, optical rotation measurement, melting point determination, HR-ESI-MS, antibacterial assay, cytotoxicity assay, HMBC, COSY, antimalarial assays, FT-IR, HCl hydrolysis
Found