Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as an intramolecular cyclization of a pyridine basic backbone with a phenyl group. The structure and relative configuration of the new compounds were established by spectroscopic means. The new compound 1 and the known compound 3 showed antibiotic activities against the clinically relevant microorganism, Staphylococcus epidermidis, with IC50 values of 24 μM and 4 μM, respectively.
antibiotic, Trichoderma, Marine fungus, pyridones
NCBI PubMed ID: 24663111Publication DOI: 10.3390/md12031208Journal NLM ID: 101213729Publisher: Basel, Switzerland: Molecular Diversity Preservation International
Correspondence: Wu B
; Oesker V ; Wiese J ; Schmaljohann R ; Imhoff JF
Institutions: Kieler Wirkstoff-Zentrum am GEOMAR Helmholtz Zentrum für Ozeanforschung Kiel, Kiel, Germany
Methods: 13C NMR, 1H NMR, NMR-2D, IR, ESI-MS, HPLC, UV, extraction, optical rotation measurement, biological assay, antimicrobial assay
Found