In the course of searching for new antifungal substances in Malbranchea spp., two new furanone glycosides, malfilamentosides A (1) and B (2), were isolated from Malbranchea filamentosa along with a furanone derivative, 4-benzyl-3-phenyl-5H-furan-2-one (3) and a dioxopiperazine derivative, amauromine, and an anthraquinone, erythroglaucine. The structures of 1 and 2 were established by spectroscopic and chemical investigation. Malfilamentosides A (1) and B (2) are the first examples of the glycosides of the furanone derivative from the fungal sources.
glycoside, Malbranchea filamentosa, malfilamentoside A, malfilamentoside B, 4-benzyl-3-phenyl-5H-furan-2-one, 6-O-methyl-N-acetyl-D-glucosamine
Publication DOI: 10.2520/myco.58.1Journal NLM ID: 101654100Publisher: Tokyo: Japanese Society of Mycotoxicology
Institutions: Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan, Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba, Japan
Methods: 13C NMR, 1H NMR, NMR-2D, IR, TLC, acid hydrolysis, HPLC, UV, extraction, optical rotation measurement, CD, CC, ESI-TOF-MS, melting point determination, antifungal activity test
Found