Hirtusneanoside, a new O-deoxyglycoside of a dimeric tetrahydroxanthone, was isolated from the lichen Usnea hirta. Its structure, including the absolute configuration, was determined by means of extensive spectroscopic data (UV, IR, MS, CD, 1D and 2D NMR) and chemical degradation. Hirtusneanoside has a unique structure comprising L-rhamnopyranoside of a tetrahydroxanthone dimer and showed growth inhibitory activities against Gram-positive bacteria
absolute configuration, lichen, Usnea hirta, hirtusneanoside
NCBI PubMed ID: 17822296Publication DOI: 10.1021/np070079mJournal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Correspondence: Rezanka T
Institutions: Institute of Microbiology, Prague, Czech
Methods: 13C NMR, 1H NMR, NMR-2D, IR, FAB-MS, TLC, UV, enzymatic digestion, extraction, CD, oxidation, RP-HPLC, antibacterial assay, DEPT, HR-FAB-MS