To contribute to the possibilities to study the ability of oligosaccharide fragments of hyaluronic acid to induce angiogenesis, several hyaluronic-acid-related oligosaccharides and their 6-O-sulfated analogues were synthesised as their 4-methoxyphenyl glycosides having 2-acetamido-2-deoxy-D-glucopyranose at the reducing end. In all syntheses described, the D-glucopyranosyluronic acid residue was obtained by oxidation at C-6 of a corresponding D-glucopyranosyl residue after construction of the oligosaccharide backbone, using pyridinium dichromate and acetic anhydride.
oxidation, hyaluronic acid oligosaccharides, hyaluronic acid sulfated analogues
NCBI PubMed ID: 9741075Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: kame@boc.chem.uu.nl
Institutions: Bijvoet Center, Department of Bio-Organic Chemistry, Utrecht University, Utrecht, The Netherlands, Agrotechnological Research Institute (ATO-DLO), Wageningen, The Netherlands, TheInstitute of Physical andChemical Research(RIKEN),Wako-shi,Hirosawa 2-1, Saitama, 350-01, Japan
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