Two new diphenyl ethers (1 and 2) and four new phenolic bisabolane sesquiterpenoids (3-6), together with five known related derivatives, were isolated from the culture of the endophytic fungus Aspergillus flavus QQSG-3 obtained from a fresh branch of Kandelia obobata, which was collected from Huizhou city in the province of Guangdong, China. The structures of compounds 1-6 were determined by analyzing NMR and HRESIMS data. The absolute configurations of 5 and 6 were assigned by comparing their experimental ECD spectra with those reported for similar compounds in the literature. All isolates were evaluated for their -glucosidase inhibitory activity, of which compounds 3, 5, 10, and 11 showed strong inhibitory effects with IC50 values in the range of 1.5-4.5 M.
mangrove endophytic fungus, Aspergillus flavus, α-glucosidase inhibitors
NCBI PubMed ID: 30200400Publication DOI: 10.3390/md16090307Journal NLM ID: 101213729Publisher: Basel, Switzerland: Molecular Diversity Preservation International
Correspondence: Wu YN
; Huang XS ; Pan YH ; Chen Y ; Yan T ; Cao WH ; Liu ZM ; She ZG
Institutions: School of Chemistry, Sun Yat-Sen University, Guangzhou, China, South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, School of Marine Sciences, Sun Yat-Sen University, Guangzhou, China, State Key Laboratory of Applied Microbiology, Southern China, Guangdong Institute of Microbiology, Guangzhou, China, CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China
Methods: IR, HPLC, UV, extraction, HR-ESI-MS, inhibition assay, optical rotation measurements, TLs
Found