To discover antimicrobial agents from higher fungi, mannonerolidol (3), a new nerolidol mannoside, together with known schizostatin (1) and nerolidol (2) were isolated from an antimicrobial fraction of the culture broth of Schizophyllum commune. Structures of these compounds were determined through spectroscopic methods. Compounds 1 and 3 exhibited antimicrobial activities against plant pathogenic fungi Rhizoctonia solani, Diaporthe sp., Botrytis cinerea, and Alternaria solani and bacteria Bacillus subtilis and Staphylococcus aureus.
Schizophyllum commune, mannonerolidol
NCBI PubMed ID: 30542161Publication DOI: 10.1038/s41429-018-0130-3Journal NLM ID: 0151115Publisher: London: Nature Publishing Group
Correspondence: Yun BS
Institutions: Division of Biotechnology and Advanced Institute of Environmental and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan-si, South Korea, Agricultural Microbiology Division, National Academy of Agricultural Science, Rural Development Administration, Wanju-gun, South Korea
Methods: 13C NMR, 1H NMR, NMR-2D, DNA sequencing, acid hydrolysis, UV, extraction, optical rotation measurement, CC, cell growth, HR-ESI-MS, RP-MPLC, antifungal assay
Found