A new sordarin derivative, trichosordarin A (1), with a unique norditerpene aglycone was isolated from the culture of a marine-sediment-derived fungal strain, Trichoderma harzianum R5. Its structure and relative configuration were unequivocally identified by a combination of 1D/2D NMR, IR, and mass spectrometric methods. Compound 1 was assayed to be toxic to the marine zooplankton Artemia salina.
Trichoderma harzianum, norditerpene, trichosordarin A
NCBI PubMed ID: 30777455Publication DOI: 10.1080/14786419.2019.1574782Journal NLM ID: 101167924Publisher: Milton Park, UK : Taylor & Francis Health Sciences
Correspondence: Ji NY
Institutions: Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, China, Naval Aviation University, Yantai, China
Methods: 13C NMR, 1H NMR, EI-MS, NMR-2D, IR, DNA techniques, TLC, biological assays, UV, extraction, optical rotation measurement, CC, cell growth, evaporation, ECD, HR-EI-MS, VLC
Found