Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
NCBI PubMed ID: 26074894Publication DOI: 10.3389/fmicb.2015.00496Journal NLM ID: 101548977Publisher: Lausanne: Frontiers Research Foundation
Correspondence: Jochen Schmid <j.schmid
tum.de>
Institutions: Chair of Chemistry of Biogenic Resources, Technische Universität München Straubing, Germany, Institute of Fundamental Sciences, Massey University Palmerston North, New Zealand, The MacDiarmid Institute for Advanced Materials and Nanotechnology Palmerston North, New Zealand
Bacteria produce a wide range of exopolysaccharides which are synthesized via different biosynthesis pathways. The genes responsible for synthesis are often clustered within the genome of the respective production organism. A better understanding of the fundamental processes involved in exopolysaccharide biosynthesis and the regulation of these processes is critical toward genetic, metabolic and protein-engineering approaches to produce tailor-made polymers. These designer polymers will exhibit superior material properties targeting medical and industrial applications. Exploiting the natural design space for production of a variety of biopolymer will open up a range of new applications. Here, we summarize the key aspects of microbial exopolysaccharide biosynthesis and highlight the latest engineering approaches toward the production of tailor-made variants with the potential to be used as valuable renewable and high-performance products for medical and industrial applications.
biosynthesis, gene clusters, Bacterial exopolysaccharides, polysaccharide engineering, tailor-made exopolysaccharides
Structure type: homopolymer
Location inside paper: fig.2G, cellulose
Trivial name: cellulose, β-(1,4)-glucan, cellulose, β-(1,4)-glucan
Compound class: EPS, O-polysaccharide, cell wall polysaccharide, glucan, polysaccharide
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192
Comments, role: review
NCBI Taxonomy refs (TaxIDs): 28448,
1296990Reference(s) to other database(s): GTC:G75830OM, GlycomeDB:
27885, CCSD:
50051, CBank-STR:4229
Show glycosyltransferases
There is only one chemically distinct structure:
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(later renamed to: Komagataeibacter xylinus)