Nine new fungal metabolites, one phthalide derivative, acremonide (1), and eight isocoumarin derivatives, acremonones A-H (2-9), were isolated from the mangrove-derived fungus Acremonium sp. PSU-MA70 together with 10 known compounds. Their structures were determined by NMR analysis. The known 8-deoxytrichothecin and trichodermol exhibited moderate antifungal activity against Candida albicans and Cryptococcus neoformans, respectively.
Candida albicans, antifungal activity, Cryptococcus neoformans, acremonide, acremonones, Acremonium sp. PSU-MA70
NCBI PubMed ID: 22524636Publication DOI: 10.1021/np200885eJournal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Correspondence: Rukachaisirikul V
Institutions: National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Thailand, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Thailand, Natural Products Research Center and Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Thailand
Methods: 13C NMR, 1H NMR, IR, DNA sequencing, TLC, UV, optical rotation measurement, CC, cell growth, melting point determination, DNA extraction, antifungal activity test, HR-EI-MS
Found