Four new cyclohexene derivatives cladoscyclitols A-D (1-4) and one new ribofuranose phenol derivative 4-O-α-D-ribofuranose-2-pentyl-3-phemethylol (5) were obtained from the EtOAC extract of the mangrove-derived endophytic fungus Cladosporium sp. JJM22. The structures were elucidated by extensive NMR and MS analysis, while the absolute configurations of the stereogenic carbons were established based on quantum-chemical electronic circular dichroism calculations or comparison of the optical rotations with those of related compounds. Compounds 2 and 5 displayed potent inhibitory activity against α-glucosidase with the IC50 values of 2.95 and 2.05 μM, respectively.
Ceriops tagal, Cladosporium sp., ribofuranose phenol, cyclohexene derivatives
NCBI PubMed ID: 33387642Publication DOI: 10.1016/j.fitote.2020.104823Journal NLM ID: 16930290RPublisher: Elsevier
Correspondence: Guang-Ying Chen
Institutions: Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China, State Key Laboratory of Quality Study of Traditional Chinese Medicine, Macau University of Science and Technology, China
Methods: 13C NMR, 1H NMR, NMR-2D, IR, HPLC, extraction, optical rotation measurement, fermentation, HR-ESI-MS, antibacterial assay, taxonomy studies, ECD, silica gel chromatography, identification, α-glucosidase activity
Found