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Structure type: polymer chemical repeating unit
Trivial name: polysaccharide BSF‑A
Contained glycoepitopes: IEDB_136906,IEDB_137472,IEDB_1394182,IEDB_141794,IEDB_151528,IEDB_190606,IEDB_983930,SB_7

• Article ID: 9516
  da Silva Milhorini S, de Lima Bellan D, Zavadinack M, Simas FF, Smiderle FR, de Santana-Filho AP, Sassaki GL, Iacomini M "Antimelanoma effect of a fucoxylomannan isolated from Ganoderma lucidum fruiting bodies" - Carbohydrate Polymers 294 (2022) 119823
  

  A fucoxylomannan (FXM) was isolated from the mushroom Ganoderma lucidum through alkaline extraction followed by dialysis, freeze-thawing, and fractionation by Fehling's solution. The main chain of FXM presented α-D-Manp-(1→4)-linked units, and some of them were branched at O-6 position by α-L-Fucp-(1→2)-β-D-Xylp groups. Its Mw was 35.9 kDa. FXM was tested on melanoma B16-F10 cells and it showed cell viability and cell density reduction, as well as antiproliferative effect, through cell cycle arrest. Additionally, the anchorage-independent clonogenic capacity of such cells was significantly reduced by FXM, decreasing the number of cells by colony and the colonies area. No effect on viability neither in proliferation of non-tumoral Balb c/3T3 fibroblasts was observed. These results indicate that FXM is a promising anti-proliferative compound impairing pivotal tumorigenic mechanisms, eliciting this polysaccharide to be further explored as an antimelanoma drug.

  heteropolysaccharide, antitumor activity, Ganoderma lucidum, antimelanoma, fucoxylomannan

  NCBI PubMed ID: 35868772
  Publication DOI: 10.1016/j.carbpol.2022.119823
  Journal NLM ID: 8307156
  Publisher: Elsevier
  Correspondence: M. Iacomini
  Institutions: Department of Biochemistry and Molecular Biology, Federal University of Paraná, CEP 81531-980 Curitiba, PR, Brazil, Department of Cell Biology, Federal University of Paraná, Curitiba, PR, Brazil, Faculdades Pequeno Príncipe, CEP 80230-020 Curitiba, PR, Brazil, Instituto de Pesquisa Pelé Pequeno Príncipe, CEP 80240-020 Curitiba, PR, Brazil
  Methods: 13C NMR, 1H NMR, methylation, NMR-2D, GC-MS, sugar analysis, GLC, HPSEC, extraction, acetylation, statistical analysis, partial hydrolysis, flow cytometry analysis, cell viability assay, cytotoxicity assay, antitumor activity assay, DEPT-135, soft agar assay, cell cycle analysis
  
   
  
  Boletus speciosus Frost
  CSDB ID 51746 (all data & tools)

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Structure type: structural motif or average structure
Trivial name: polysaccharide BSF-X
Contained glycoepitopes: IEDB_136906,IEDB_137472,IEDB_1394182,IEDB_141794,IEDB_151528,IEDB_190606,IEDB_983930,SB_7

• Article ID: 9639
  Liu H, Liu X, Xie J, Chen S "Structure, function and mechanism of edible fungus polysaccharides in human beings chronic diseases" - Food Science and Technology (Brazil) 43 (2023) e111022
  

  The feasibility of human nutritional supplementation is imperative. As a part of daily diet, edible fungus polysaccharides have a variety of health promoting effects, especially for the prevention of chronic diseases. Based on the extensive collection and collation of relevant research datas, the beneficial effects of edible fungus polysaccharides on various chronic diseases were analyzed, and the structure and functional mechanism of edible fungus polysaccharides with anti-chronic disease properties were summarized in this current review. Based on a comprehensive analysis of the current researchs on edible fungus polysaccharides, it was considered that edible fungus polysaccharides can be used as the material basis of anti-chronic disease drugs. In addition, the relevant contents can also provide some reference for the selection and development of anti-chronic disease drugs.

  active structure, chronic diseases, edible fungus polysaccharides, mechanism and pathway

  Publication DOI: 10.1590/fst.111022
  Publisher: Sociedade Brasileira de Ciência e Tecnologia de Alimentos (ISSN: 0101-2061)
  Correspondence: H. Liu ; J. Xie
  Institutions: The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Nutrition and Food Hygiene, School of Public HealGuizhou Medical University, Guizhou, China, Guizhou Provincial Engineering Research Center of Food Nutrition and Health, Guizhou Medical University, Guizhou, China, Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Guizhou Medical University, Guiyang, China
  
   
  
  Boletus speciosus Frost
  CSDB ID 41454 (all data & tools)