Three new aromatic polyketides (±)-puniceusone A (1), (±)-2,3-dihydroxypropyl 6-ethyl-2,4-dihydroxy-3-methylbenzoate (2), (5-ethyl-3-hydroxy-2-methyl) phenyl-β-D-glucoside (3), and two new isoquinoline alkaloids puniceusine O (4) and (±)-puniceusine P (5), were isolated from the deep-sea-derived fungus Aspergillus puniceus SCSIO z021. Their structures were determined by spectroscopic analyses. Compound 1 contains an uncommon hydrogenated benzochromene scaffold, 3 and 4 are glycosides, and 5 is unexpectedly composed of a polysubstituted benzyl and an isoquinoline nucleus.
Structures, Aspergillus, polyketides, marine-derived fungi, isoquinoline alkaloids
Publication DOI: 10.1016/j.tet.2022.133067Journal NLM ID: 2984170RPublisher: Pergamon Press
Correspondence: S.H. Qi
Institutions: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301, Guangdong, Chin
Methods: 13C NMR, 1H NMR, NMR-2D, IR, TLC, acid hydrolysis, HPLC, UV, extraction, optical rotation measurement, fermentation, HR-ESI-MS, antibacterial assay
Found