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1. Compound ID: 23282
Structure type: fragment of a bigger structure
; 3350000
Trivial name: (1,4)-α-glucan, proteoglycan complex, ABM
Contained glycoepitopes: IEDB_140629,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_420417,IEDB_420418,IEDB_420421,IEDB_857742,IEDB_983931,SB_192
The structure is contained in the following publication(s):
- Article ID: 9550
Menezes TMF, Campelo MDS, Lima ABN, Neto JFC, Saraiva MM, Costa de Sousa JA, da Costa Gonzaga ML, Leal LKAM, Ribeiro MENP, Ricardo NMPS, Soares SDA "Effects of polysaccharides isolated from mushrooms (Lentinus edodes Berk or Agaricus blazei Murill) on the gelation of Pluronic® F127" -
Colloids and Surfaces. A, Physicochemical and Engineering Aspects 642 (2022) 128684
This study evaluated the effects of polysaccharides isolated from Lentinus edodes Berk and Agaricus blazei Murill mushrooms on the gelation process of the Pluronic® F127 (F127) copolymer. The structural characterization of these biopolymers suggested the isolation of an β-glucan L. edodes Berk (LEB) and a proteoglycan complex A. blazei Murill (ABM). Both polysaccharides showed good rheological properties for developing pharmaceutical formulations with antioxidant activity and low cytotoxicity in human neutrophils. The characterization of the gels formed from the mixture of polysaccharides with aqueous solutions of F127 showed that the presence of these biopolymers reduces the temperature range in which F127 remains in the gel phase (G’ > G’’). Furthermore, the thermoresponsive behavior of F127 was not lost, which favors the development of hydrogels with potential for topical use.
polysaccharide, Agaricus blazei, Lentinus edodes, copolymer, Pluronic F127
Publication DOI: 10.1016/j.colsurfa.2022.128684Journal NLM ID: 9891752Publisher: Amsterdam, New York: Elsevier
Correspondence: M.E.N.P. Ricardo
; N.M.P.S. Ricardo ; S.D.A. Soares
Institutions: Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Federal University of Ceará, Campus of Pici, Zip Code: 60440-900 Fortaleza, CE, Brazil, Center for Pharmaceutical and Cosmetic Studies, Department of Pharmacy, Federal University of Ceará, Porangabussu Campus, Zip Code: 60430-370 Fortaleza, CE, Brazil
Methods: 13C NMR, 1H NMR, FTIR, GPC, extraction, statistical analysis, antioxidant activities, cytotoxicity assay, rheological study, AFM, intrinsic viscosity measurement, F127-polysaccharides gels preparation
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2. Compound ID: 23283
Structure type: fragment of a bigger structure
; 954000, 3350000
Trivial name: polysaccharide LEB, proteoglycan complex, ABM
Compound class: β-glucan
Contained glycoepitopes: IEDB_142488,IEDB_144998,IEDB_146664,IEDB_158538,IEDB_2346541,IEDB_983931,SB_192
The structure is contained in the following publication(s):
- Article ID: 9550
Menezes TMF, Campelo MDS, Lima ABN, Neto JFC, Saraiva MM, Costa de Sousa JA, da Costa Gonzaga ML, Leal LKAM, Ribeiro MENP, Ricardo NMPS, Soares SDA "Effects of polysaccharides isolated from mushrooms (Lentinus edodes Berk or Agaricus blazei Murill) on the gelation of Pluronic® F127" -
Colloids and Surfaces. A, Physicochemical and Engineering Aspects 642 (2022) 128684
This study evaluated the effects of polysaccharides isolated from Lentinus edodes Berk and Agaricus blazei Murill mushrooms on the gelation process of the Pluronic® F127 (F127) copolymer. The structural characterization of these biopolymers suggested the isolation of an β-glucan L. edodes Berk (LEB) and a proteoglycan complex A. blazei Murill (ABM). Both polysaccharides showed good rheological properties for developing pharmaceutical formulations with antioxidant activity and low cytotoxicity in human neutrophils. The characterization of the gels formed from the mixture of polysaccharides with aqueous solutions of F127 showed that the presence of these biopolymers reduces the temperature range in which F127 remains in the gel phase (G’ > G’’). Furthermore, the thermoresponsive behavior of F127 was not lost, which favors the development of hydrogels with potential for topical use.
polysaccharide, Agaricus blazei, Lentinus edodes, copolymer, Pluronic F127
Publication DOI: 10.1016/j.colsurfa.2022.128684Journal NLM ID: 9891752Publisher: Amsterdam, New York: Elsevier
Correspondence: M.E.N.P. Ricardo
; N.M.P.S. Ricardo ; S.D.A. Soares
Institutions: Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Federal University of Ceará, Campus of Pici, Zip Code: 60440-900 Fortaleza, CE, Brazil, Center for Pharmaceutical and Cosmetic Studies, Department of Pharmacy, Federal University of Ceará, Porangabussu Campus, Zip Code: 60430-370 Fortaleza, CE, Brazil
Methods: 13C NMR, 1H NMR, FTIR, GPC, extraction, statistical analysis, antioxidant activities, cytotoxicity assay, rheological study, AFM, intrinsic viscosity measurement, F127-polysaccharides gels preparation
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