Three new compounds, including a pair of chromone derivatives (1-2), and an acetophenone glucoside (3), together with three known compounds (4-6), were isolated from the mangrove endophytic fungus Mycosphaerella sp. L3A1. Their structures were elucidated by HR-ESI-MS analysis and extensive spectroscopic data. The absolute configurations of new compounds were determined using single-crystal X-ray diffraction analysis, electronic circular dichroism (ECD) calculations and chemical hydrolysis. In bioassays, compound 4 showed moderate cytotoxic activity against MDA-MB-435, HCT116, and SNB19 with IC50 values in the range of 18.5-26.29 μM.
cytotoxic activity, secondary metabolite, mangrove endophytic fungus, Mycosphaerella
NCBI PubMed ID: 36318651Publication DOI: 10.1002/cbdv.202200998Journal NLM ID: 101197449Publisher: Verlag Helvetica Chimica Acta
Correspondence: J. Yuan
; Z. She
Institutions: School of Chemistry, Sun Yat-sen University, Guangzhou, 510006, P. R. China, Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, P. R. China, Guangdong Key Laboratory of Natural Medicine Research and Development & College of Pharmacy, Guangdong Medical University, Dongguan, 523808, P. R. China, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, P. R. China
Methods: 13C NMR, 1H NMR, NMR-2D, IR, X-ray, HPLC, UV, fermentation, HR-ESI-MS, ECD
Found