Found 1 structure.
Displayed structure 1
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1. Compound ID: 23616
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a-D-Manp2Me-(1-2)-+
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-6)-{{{-b-D-Glcp-(1-6)-}}}b-D-Galp-(1-3)-a-L-Fucp-(1-4)-b-D-Galp-(1-6)-a-D-Galp-(1- |
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Structure type: structural motif or average structure
Compound class: polysaccharide
Contained glycoepitopes: IEDB_130701,IEDB_135614,IEDB_136044,IEDB_136045,IEDB_136906,IEDB_137472,IEDB_140529,IEDB_141794,IEDB_141806,IEDB_142488,IEDB_142489,IEDB_144562,IEDB_144983,IEDB_146664,IEDB_151528,IEDB_152206,IEDB_152214,IEDB_153201,IEDB_167069,IEDB_174333,IEDB_190606,IEDB_241101,IEDB_983930,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_44,SB_67,SB_7,SB_72,SB_86,SB_88
The structure is contained in the following publication(s):
- Article ID: 9695
Wei S, Chen X, Wang Y, Tong L, Wang L, Han Q, Guo D, Ren B "Polysaccharide from Boletus aereus ameliorates DSS-induced colitis in mice by regulating the MANF/MUC2 signaling and gut microbiota" -
International Journal of Biological Macromolecules 266(Pt1) (2024) ID 131232
Inflammatory bowel diseases (IBD) are chronic inflammatory conditions characterized by disruptions in the colonic mucus barrier and gut microbiota. In this study, a novel soluble polysaccharide obtained from Boletus aereus (BAP) through water extraction was examined for its structure. The protective effects of BAP on colitis were investigated using a DSS-induced mice model. BAP was found to promote the expression of intestinal mucosal and tight junction proteins, restore the compromised mucus barrier, and suppress the activation of inflammatory signaling. Moreover, BAP reshape the gut microbiota and had a positive impact on the composition of the gut microbiota by reducing inflammation-related microbes. Additionally, BAP decreased cytokine levels through the MANF-BATF2 signaling pathway. Correlation analysis revealed that MANF was negatively correlated with the DAI and the level of cytokines. Furthermore, the depletion of gut microbiota using antibiotic partially inhabited the effect of BAP on the activation of MANF and Muc2, indicating the role of gut microbiota in its protective effect against colitis. In conclusion, BAP had an obvious activation on MANF under gut inflammation. This provides new insights into the prospective use of BAP as a functional food to enhance intestinal health
Structural characterization, gut microbiota, Boletus aereus polysaccharide
NCBI PubMed ID: 38554896Publication DOI: 10.1016/j.ijbiomac.2024.131232Journal NLM ID: 7909578Publisher: Butterworth-Heinemann
Correspondence: Wang L
; Guo D ; Ren B
Institutions: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, China, College of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing, China, BIOSYST-MeBioS, Faculty of Bioscience Engineering, Leuven, Belgium
Methods: 13C NMR, 1H NMR, NMR-2D, ELISA, acid hydrolysis, HPAEC, GC, Western blotting, biological assays, extraction, methylation analysis, reduction, dialysis, SEM, Sevag method, qRT-PCR, FT-IR, immunofluorescence, staining, SEC-MALLS-RI
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