Show legend Show as text

Structure type: oligomer
Trivial name: saikosaponin f, saikosaponin, saikosaponin F
Compound class: saponin glycoside
Contained glycoepitopes: IEDB_136105,IEDB_141806,IEDB_142488,IEDB_146664,IEDB_225177,IEDB_241101,IEDB_885823,IEDB_983931,SB_192

• Article ID: 9769
  Kimura Y, Ohminami H, Okuda H, Tani T, Arichi S, Hayashi T "Effects of saikosaponins on the metabolic actions of adrenaline, ACTH and insulin on the fat cells" - Chemical and Pharmaceutical Bulletin 28(6) (1980) 1788-1794
  

  Saikosaponins a and d inhibited adrenaline-induced lipolysis in fat cells isolated from epididymal adipose tissue of rats. Saikosaponins a, b1, b2, b4, c and d inhibited ACTH-induced lipolysis in the fat cells. Insulin-stimulated lipogenesis in adipose tissue was significantly reduced by saikosaponin d. Propranolol (a β-blocker) inhibited not only lipolytic actions induced by adrenaline and ACTH but also lipogenesis stimulated by insulin. In contrast to propranolol, saikosaponins b1, b2, b4 and c selectively inhibited ACTH-induced lipolysis without affecting the lipogenetic effect of insulin. The structure-activity relationship of saikosaponins is discussed.

  structure-activity relationship, saikosaponin, Bupleurum falcatum, adrenaline-induced lipolysis, ACTH-induced lipolysis, insulin-stimulated lipogenesis, fat cells

  Publication DOI: 10.1248/cpb.28.1788
  Journal NLM ID: 0377775
  WWW link: http://ci.nii.ac.jp/naid/110003662561
  Publisher: Pharmaceutical Society Of Japan
  Institutions: The Research Institute of Oriental Medicine, Kinki University, Japan, School of Medicine, Ehime University, Japan, Koshiro Chuji Shoten Co, Japan
  Methods: biological activity assays
  
   
  
  Bupleurum falcatum
  CSDB ID 118981 (all data & tools)
• Article ID: 9770
  Ishii H, Nakamura M, Seo S, Tori K, Tozyo T, Yoshimura Y "Isolation, characterization, and nuclear magnetic resonance spectra of new saponins from the roots of Bupleurum falcatum L" - Chemical and Pharmaceutical Bulletin 28(8) (1980) 2367-2373
  

  A systematic separation of a saponin fraction of the root of Bupleurum falcatum L. furnished seven new saponins, i.e., five monoacetylsaikosaponins (15-18,20) and saikosaponins-e (19) and -f (21), besides the known saikosaponins-a, -b2,-b4,-c, and -d. α-Spinasteryl β-D-glucoside (22) was also isolated. The structures of these new saponins were determined by means of carbon-13 nuclear magnetic resonance spectroscopy.

  13C NMR spectroscopy, Bupleurum falcatum, separation of saikosaponins, saikogenins A-G, saikosaponin-a, saikosaponin-b1, saikosaponin-b2, saikosaponin-b3, saikosaponin-b4, saikosaponin-c, saikosaponin-d, saikosaponin-e, saikosaponin-f, monoacetylsaikosaponin, α-spinasteryl β-D-glucoside, acetylation shift

  Journal NLM ID: 0377775
  WWW link: http://ci.nii.ac.jp/naid/110003624035
  Publisher: Pharmaceutical Society Of Japan
  Institutions: Shionogi Research Laboratory, Shionogi and Co, Japan
  Methods: 13C NMR, 1H NMR, TLC, melting point determination, acetylation analysis
  
   
  
  Bupleurum falcatum
  CSDB ID 118991 (all data & tools)
• Article ID: 9895
  Arichi S, Tani T, Kubo M "Studies on Bupleuri radix and saikosaponin. 3. Quantitative analysis of saikosaponin of commercial Bupleuri radix" - Kinki Daigaku Igaku Zasshi = Medical journal of Kinki University [Japanese] 4 (1979) 235-241
  

  The method of quantitative analysis of each saikosaponin which is one of the pharmacological active principles of BUPLEURI RADIX (Chai-Hu, saiko) was presented by the combination of thin-layer chromatography and high performance liquid chromatography. By means of the new method, the contents of saikosaponin in the commercial BUPLEURI RADIX were studied.

  Publisher: Sayama-Cho: Kinki Daigaku Igakkai
  Institutions: The Research Institute of Oriental Medicine, Kinki University, Osaka, Japan
  Methods: TLC, HPLC
  
   
  
  Bupleurum
  CSDB ID 142746 (all data & tools)
• Article ID: 9973
  Tori K, Seo S, Yoshimura Y, Nakamura M, Tomita Y, Ishii H "Carbon-13 NMR spectra of saikosaponins A, C, D, and F isolated from Bupleurum falcatum L." - Tetrahedron Letters 17(46) (1976) 4167-4170
  
  Publication DOI: 10.1016/S0040-4039(00)74624-7
  Journal NLM ID: 2984819R
  Publisher: Elsevier
  Methods: NMR
  
   
  
  Bupleurum falcatum
  CSDB ID 148884 (all data & tools)

Show legend Show as text

Structure type: oligomer
Trivial name: chikusaikoside II
Compound class: saponin glycoside
Contained glycoepitopes: IEDB_136105,IEDB_141806,IEDB_142488,IEDB_146664,IEDB_225177,IEDB_241101,IEDB_885823,IEDB_983931,SB_192

• Article ID: 10041
  Ding J, Fujino H, Kasai R, Fujimoto N, Tanaka O, Zhou J, Matsuura H, Fuwa T "Chemical evaluation of Bupleurum species collected in Yunnan, China" - Chemical and Pharmaceutical Bulletin 34 (1986) 1158-1167
  

  Saponins were isolated from roots of Bupleurum marginatum (Zhuye-Chaihu), B. marginatum var. stenophyllum (Zezhuye-Chaihu) and B. rockii (Lijiang-Chaihu) collected in Yunnan, China, and identified. For the evaluation of these plants as a medicine, quantitative analysis of pharmacologically active saponins, saikosaponins-a (1) and -d (3), in the plants was also conducted in comparison with B. falcatum and B. chinensis.

  saikosaponin, Umbelliferae, Chinese Bupleuri radix, Saiko, Chaihu, Bupleurum marginatum, B. marginatum var. stenophyllum, Bupleurum rockii, Yunnan medicinal plant, acetylsaikosaponin

  Journal NLM ID: 0377775
  WWW link: http://ci.nii.ac.jp/naid/110003626207
  Publisher: Pharmaceutical Society Of Japan
  Institutions: Kunming Institute of Botany, Academia Sinica, Kunming, China, Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Hiroshima, Japan, Central Research Laboratories, Wakunaga Pharmaceutical Co., Ltd., Osaka, Japan
  Methods: 13C NMR, 1H NMR, gel filtration, deacetylation, MS, HPLC
  
   
  
  Bupleurum marginatum var. stenophyllum, Bupleurum marginatum
  CSDB ID 119369 (all data & tools)
• Article ID: 10242
  Ogawa K, Koshino H "The quality of dry extract preparations of Sino Japanese medicine. II. Elution of constituents of Bupleuri radix and Scutellaria root into decoction" - Ishikawa-ken Eisei Kogai Kenkyusho Nenpo [Japanese] 27 (1990) 272-279
  
   
  
  Bupleurum, Scutellaria
  CSDB ID 131141 (all data & tools)
• Article ID: 10308
  Jo PH, Seong RS, Bae HH, Soh WY, Cho DY "Saikosaponin contents in Bupleurum falcatum root produced by tissue culture" - Saengyak Hakhoechi = Korean journal of pharmacognosy [Korean] 21 (1990) 205-209
  
  Journal NLM ID: 9713418
  Publisher: Seoul : Hanguk Saengyak Hakhoe
  Methods: HPLC
  
   
  
  Bupleurum falcatum
  CSDB ID 148289 (all data & tools)
• Article ID: 10311
  Takai N, Kanazawa H, Matsushima Y, Nagata Y, Tomoda M "High-performance liquid chromatography of crude drugs with chemically modified porous glass. Analysis of acidic saponins of ginseng, Bupleurum root and glycyrrhiza" - Seisan Kenkyu [Japanese] 41 (1989) 773-776
  
  Publisher: Institute of Industrial Science, the University of Tokyo
  Methods: HPLC
  
   
  
  Bupleurum
  CSDB ID 148411 (all data & tools)