Six steroidal glycosides were isolated from the fresh leaves of Aspidistra elatior BLUME (Liliaceae) and the structures of these glycosides, tentatively named glycosides A (1), B (2), C (3), D (4), E (5) and F (6), were established to be neopentologenin 5-O-β-D-glucopyranoside (1), 26-O-β-D-glucopyranosyl 22-methoxy-5β-furostane-1β,3β,4β,5β,26-pentaol 5-O-β-D-glucopyranoside (2), aspidistrin (3), 26-O-β-D-glucopyranosyl 22-methoxy-5β-furostane-1β,2β,3β,4β,5β,26-hexaol 5-O-β-D-glucopyranoside (4), methyl proto-aspidistrin (5) and magnesium 26-O-β-D-glucopyranosyl 22-methoxy-5β-furostane-1β,3β,4β,5β,26-pentahydroxy-2β-yl-sulfate monohydroxide (6), respectively. The last compound is the first sulfated steroidal glycoside to be isolated from a Liliaceous plant.
leaf, diosgenin, steroidal glycoside, Liliaceae, spirostanol glycoside, furostanol glycoside, Aspidistra elatior, neopentologenin, aspidistrin, sulfated steroidal glycoside
Publication DOI: 10.1248/cpb.32.1451Journal NLM ID: 0377775WWW link: http://ci.nii.ac.jp/naid/110003624920Publisher: Pharmaceutical Society Of Japan
Institutions: School of Pharmaceutical Sciences, Showa University, Tokyo, Japan, Kyoto College of Pharmacy, Kyoto, Japan
Methods: 13C NMR, 1H NMR, IR, TLC, acid hydrolysis, GLC, enzymatic digestion, solvolysis, melting point determination, PPC, acetylation analysis
Found