By monitoring the inhibitory effect on ethanol absorption in rats, new active saponins named elatosides A and B were isolated from the bark of Aralia elata SEEM. together with elatosides C and D. The structures of elatosides A, B, C, and D were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of several oleanolic acid oligoglycosides on ethanol absorption have been examined and some structure-activity relationships have been found.
structure-activity relationship, Aralia elata, ethanol absorption inhibitory effect, oleanolic acid oligoglycoside, elatoside A, elatoside B
Journal NLM ID: 0377775WWW link: http://ci.nii.ac.jp/naid/110003630349Publisher: Pharmaceutical Society Of Japan
Institutions: Kyoto Pharmaceutical University, Kyoto, Japan
Methods: 13C NMR, 1H NMR, methanolysis, HPLC, alkaline hydrolysis, biological assay