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Structure type: oligomer
Compound class: saponin glycoside
Contained glycoepitopes: IEDB_140628,IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 10501
  Duc NM, Kasai R, Ohtani K, Ito A, Nham NT, Yamasaki K, Tanaka O "Saponins from Vietnamese Ginseng, Panax vietnamensis HA et GRUSHV. collected in central Vietnam. II" - Chemical and Pharmaceutical Bulletin 42(1) (1994) 115-122
  

  Further investigation on the saponin composition of rhizomes and roots of Panax vietnamensis HA et GRUSHV. has resulted in the isolation and structural elucidation of seven new dammarane saponins named vina-ginsenosides-R3 (12), -R4 (11), -R5 (16), -R6 (17), -R7 (6), -R8 (20), -R9 (22), together with the identification of six of known saponins including 20-gluco-ginsenoside-Rf (10), ginsenoside-Rc (4), notoginsenoside-R6 (9), quinquenoside-R1 (5), gypenoside XVII (2) and majoroside F1 (21). The structures of the novel saponins were established on the basis of chemical and spectral evidence. Vina-ginsenoside-R3 is the first naturally occurring glycoside of dammarenediol II, while vina-ginsenosides-R5 and -R6,two ocotillol-type saponins, are two other examples of saponins having the rare α-glucosyl linkage.

  ginsenoside, Vietnamese Ginseng, Panax vietnamensis, dammarane saponin, vina-ginsenoside-R3, vina-ginsenoside-R4, vina-ginsenoside-R5, vina-ginsenoside-R6, vina-ginsenoside-R7, vina-ginsenoside-R8, vina-ginsenoside-R9, dammarenediol saponin

  NCBI PubMed ID: 8124758
  Publication DOI: 10.1248/cpb.42.115
  Journal NLM ID: 0377775
  Publisher: Pharmaceutical Society Of Japan
  Institutions: The Science-Production Centre of Vietnamese Ginseng, Ho Chi Minh City University of Medicine and Pharmacy, Vietnam, Institute of Pharmaceutical Sciences, Hiroshima Univeristy School of Medicine, Japan, Suzugamine Women's College, Japan
  Methods: 13C NMR, 1H NMR, EI-MS, gel filtration, FAB-MS, partial acid hydrolysis, HPLC, enzymatic digestion, acetylation analysis, photosensitized oxydation
  
   
  
  Panax vietnamensis
  CSDB ID 270313 (all data & tools)

Show legend Show as text

Structure type: monomer
Trivial name: ginsenoside-Rh1
Compound class: saponin glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 10716
  Minh Duc N, Thoi Nham N, Kasai R, Ito A, Yamasaki K, Tanaka O "Saponins from Vietnamese Ginseng, Panax vietnamensis Ha et Grushv. collected in central Vietnam. I" - Chemical and Pharmaceutical Bulletin 41 (1993) 2010-2014
  

  From rhizomes and roots of Panax vietnamensis HA et GRUSHV., Araliaceae, commonly known as Vietnamese Ginseng, two new acetylated saponins named vina-ginsenoside-R1 (13) and vina-ginsenoside-R2 (15) were isolated. On the basis of chemical and spectral data, 13 was formulated as monoacetyl 24(S)-pseudo-ginsenoside-F_<11> and 15 was proved to be monoacetyl majonoside-R2.Besides the two new saponins and β-sitosteryl-3-O-β-D-glucopyranoside, sixteen known saponins were also isolated and identified. Dammarane saponins : ginsenoside-Rh_1 and 20(R)-ginsenoside-Rh_1 (1), ginsenosides-Rg_1 (2), -Re (3), -Rd(6), -Rb_3 (7), -Rb_2 (8), -Rb_1 (9), pseudo-ginsenoside-RS_1 (=monoacetyl ginsenoside-Re, 4), notoginsenosides-R1 (5) and -Fa (10). Ocotillol-type saponins : pseudo-ginsenoside-RT_4 (11), 24(S)-pseudo-ginsenoside-F_<11> (12), majonosides-R1 (16) and -R2 (14). Oleanolic acid saponins : ginsenoside-Ro (=chikusetsusaponin V, 17) and hemsloside-Ma3 (18), a saponin previously isolated from a cucurbitaceous plant, Hemsleya macrosperma C. Y. WU.Despite having large horizontally elongated rhizomes, the underground part of this plant contains mainly dammarane saponins and a small amount of oleanolic acid saponins. In addition, the yield of ocotillol-type saponins, especially majonoside-R2,is surprisingly very high (more than 5% and ca. half of the total yield of saponin). This characteristic saponin composition has made Vietnamese Ginseng an interesting species among Panax spp.

  ginsenoside, Vietnamese Ginseng, Panax vietnamensis, vina-ginsenoside-R1, vina-ginsenoside-R2, ocotillol-type saponin, majonoside-R2

  Journal NLM ID: 0377775
  WWW link: http://ci.nii.ac.jp/naid/110003630330
  Publisher: Pharmaceutical Society Of Japan
  Institutions: Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Hiroshima, Japan, The Science-Production Centre of Vietnamese Ginseng, Hochi Min City University of Medicine and Pharmacy, Vietnam, Suzugamine Women's College, Hiroshima, Japan
  Methods: 13C NMR, 1H NMR, EI-MS, FAB-MS, TLC, acid hydrolysis, GLC, HPLC, alkaline hydrolysis, CC
  
   
  
  Panax vietnamensis
  CSDB ID 120260 (all data & tools)