From the air-dried roots of Glycyrrhiza uralensis FISCHER collected in Xinjiang province, China ("Shinkyo-Kanzo" in Japanese), a new oleanene-type triterpene oligoglycoside named licorice-saponin L3 and a new chalcone oligoglycoside named isoliquiritin apioside were isolated together with glycyrrhizin, 18α-glycyrrhizin, apioglycyrrhizin, arabo-glycyrrhizin, licorice-saponins A3,E2,G2,and H2,and six known flavonoid glycosides. On the basis of chemical and physicochemical evidence, the structures of licorice-saponin L3 and isoliquiritin apioside were elucidated as 3β-[α-L-rhamnopyranosyl(1→2)-α-L-arabinopyranosyl(1→2)-β-D-glucuronopyranosyloxy]-22β-acetoxy-24-hydroxyolean-12-en-30-oic acid (1) and 4-O-[β-D-apiofuranosyl(1→2)-β-D-glucopyranosyl]isoliquiritigenin (6), respectively.
Glycyrrhiza uralensis, oleanene-type triterpene oligoglycoside, licorice-saponin L3, isoliquiritin apioside, licorice root, chalcone oligoglycoside
NCBI PubMed ID: 8221970Publication DOI: 10.1248/cpb.41.1567Journal NLM ID: 0377775Publisher: Pharmaceutical Society Of Japan
Institutions: Faculty of Pharmaceutical Sciences, Osaka University, Japan, Xinjiang Institute of Chemistry, Academia Sinica, China
Methods: 13C NMR, 1H NMR, gel filtration, IR, FAB-MS, GLC, methanolysis, HPLC, methylation analysis, modified Horeau's method
Found