Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
NCBI PubMed ID: 37059549Publication DOI: 10.1016/j.carbpol.2023.120821Journal NLM ID: 8307156Publisher: Elsevier
Correspondence: P.K. Singh <pankajksingh3
gmail.com>
Institutions: Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad 500037, India
Exopolysaccharides are unique polymers generated by living organisms such as algae, fungi and bacteria to protect them from environmental factors. After a fermentative process, these polymers are extracted from the medium culture. Exopolysaccharides have been explored for their anti-viral, anti-bacterial, anti-tumor, and immunomodulatory effects. Specifically, they have acquired massive attention in novel drug delivery strategies owing to their indispensable properties like biocompatibility, biodegradability, and lack of irritation. Exopolysaccharides such as dextran, alginate, hyaluronic acid, pullulan, xanthan gum, gellan gum, levan, curdlan, cellulose, chitosan, mauran, and schizophyllan exhibited excellent drug carrier properties. Specific exopolysaccharides, such as levan, chitosan, and curdlan, have demonstrated significant antitumor activity. Moreover, chitosan, hyaluronic acid and pullulan can be employed as targeting ligands decorated on nanoplatforms for effective active tumor targeting. This review shields light on the classification, unique characteristics, antitumor activities and nanocarrier properties of exopolysaccharides. In addition, in vitro human cell line experiments and preclinical studies associated with exopolysaccharide-based nanocarriers have also been highlighted.
exopolysaccharide, drug delivery, Anticancer, nanocarriers, targeted
Structure type: homopolymer ; 180000-230000
Location inside paper: table 1, cellulose
Trivial name: cellulose
Compound class: EPS
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192
Comments, role: review; Acetobacter spp. without species and strain assignment
NCBI Taxonomy refs (TaxIDs): 434
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
report error