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Ferreira JA, Domingues MR, Reis A, Figueiredo C, Monteiro MA, Coimbra MA
Aldobiouronic acid domains in Helicobacter pylori
Carbohydrate Research 346(5) (2011)
638-643
Helicobacter pylori PTAV79
(Ancestor NCBI TaxID 210,
species name lookup)
Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: gastritis [ICD11:
DA42 
];
peptic ulcer [ICD11:
DA61 , ICD11:
XN3DY ];
gastric cancer [ICD11:
2B72.Z ];
infection due to Helicobacter pylori [ICD11:
XN3DY ]
The structure was elucidated in this paperNCBI PubMed ID: 21315321Publication DOI: 10.1016/j.carres.2011.01.009Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: M.A. Coimbra <mac
ua.pt>
Institutions: Department of Chemistry, University of Guelph, Guelph, ON, Canada N1G 2W1, Medical Faculty of Porto, Porto, Portugal, QOPNA, Department of Chemistry, University of Aveiro, Campus Universitario de Santiago, Aveiro, Portugal, IPATIMUP—Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
Helicobacter pylori cell-surface glycans exert strong influences in host-microbe interplays and define the strain's immunological signature. Envisaging the development of a carbohydrate-based vaccine against the gastroduodenal pathogen H. pylori, several clinical isolates are being screened for their cell-surface glycan profile. The present work concerns H. pylori clinical specimen PTAV79 that abundantly expressed amylose-like glycans. These polysaccharides were isolated in glycan-rich fractions resultant from phenol-water extractions and purified by Bio-Gel P2. Structural studies showed that the glycans are linked to glycerol and present aldobiouronic acid domains composed of [→3)-α-D-GlcA-(1→4)-α-D-Glc-(1→] repeating units. The amylose domains were constituted by an average of 19 Glc residues and the acidic moieties had an average number of 10 aldobiouronic acid repeating units. These polysaccharides were isolated in fractions that, although hydrophilic, were rich in stearic acid, strongly suggesting that they are present as glycerolipids anchored to cell-surface.
lipopolysaccharides, Helicobacter pylori, aldobiouronic acid, a-glucans
Structure type: polymer chemical repeating unit ; n=10
Location inside paper: abstract, p.642
Trivial name: aldobiouronic acid
Compound class: cell-surface glycan
Contained glycoepitopes: IEDB_115136,IEDB_140630,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_983931,SB_192
Methods: 13C NMR, 1H NMR, NMR-2D, partial acid hydrolysis, GC-MS, ESI-MS, MALDI-TOF MS, composition analysis
Related record ID(s): 26621, 26622
NCBI Taxonomy refs (TaxIDs): 210Reference(s) to other database(s): GTC:G21958FI
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There is only one chemically distinct structure:
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Ferreira JA, Domingues MR, Reis A, Figueiredo C, Monteiro MA, Coimbra MA
Aldobiouronic acid domains in Helicobacter pylori
Carbohydrate Research 346(5) (2011)
638-643
Helicobacter pylori PTAV79
(Ancestor NCBI TaxID 210,
species name lookup)
Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: gastritis [ICD11:
DA42 ];
peptic ulcer [ICD11:
DA61 , ICD11:
XN3DY ];
gastric cancer [ICD11:
2B72.Z ];
infection due to Helicobacter pylori [ICD11:
XN3DY ]
The structure was elucidated in this paperNCBI PubMed ID: 21315321Publication DOI: 10.1016/j.carres.2011.01.009Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: M.A. Coimbra <mac
ua.pt>
Institutions: Department of Chemistry, University of Guelph, Guelph, ON, Canada N1G 2W1, Medical Faculty of Porto, Porto, Portugal, QOPNA, Department of Chemistry, University of Aveiro, Campus Universitario de Santiago, Aveiro, Portugal, IPATIMUP—Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
Helicobacter pylori cell-surface glycans exert strong influences in host-microbe interplays and define the strain's immunological signature. Envisaging the development of a carbohydrate-based vaccine against the gastroduodenal pathogen H. pylori, several clinical isolates are being screened for their cell-surface glycan profile. The present work concerns H. pylori clinical specimen PTAV79 that abundantly expressed amylose-like glycans. These polysaccharides were isolated in glycan-rich fractions resultant from phenol-water extractions and purified by Bio-Gel P2. Structural studies showed that the glycans are linked to glycerol and present aldobiouronic acid domains composed of [→3)-α-D-GlcA-(1→4)-α-D-Glc-(1→] repeating units. The amylose domains were constituted by an average of 19 Glc residues and the acidic moieties had an average number of 10 aldobiouronic acid repeating units. These polysaccharides were isolated in fractions that, although hydrophilic, were rich in stearic acid, strongly suggesting that they are present as glycerolipids anchored to cell-surface.
lipopolysaccharides, Helicobacter pylori, aldobiouronic acid, a-glucans
Structure type: polymer chemical repeating unit ; n=19
Location inside paper: abstract, p.642
Trivial name: amylose
Compound class: cell-surface glycan
Contained glycoepitopes: IEDB_140629,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_420417,IEDB_420418,IEDB_420421,IEDB_857742,IEDB_983931,SB_192
Methods: 13C NMR, 1H NMR, NMR-2D, partial acid hydrolysis, GC-MS, ESI-MS, MALDI-TOF MS, composition analysis
Related record ID(s): 26194, 26622
NCBI Taxonomy refs (TaxIDs): 210Reference(s) to other database(s): GTC:G57610AB
Show glycosyltransferases
There is only one chemically distinct structure:
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