A novel sesquiterpene lactone, 2-α-βP-d-glucopyranosyl-Δ1(10),4(5)-germacradien-6α-7β-11β-olide (ratibinolide III), and four known compounds, ratibinolide I, ratibinolide II, hispidulin, and pedalitin, have been isolated and characterized from a cytotoxic extract of Ratibida latipalearis aerial parts. Of these compounds only the second two exhibited significant activity against P-388 murine lymphocytic leukaemia. The proposed structure of the new compound was based on spectroscopic and chemical evidence.
Asteraceae, Ratibida latipalearis, sesquiterpene lactone, ratibinolide III, 2-α-β-d-glucopyranosyl-Δ1(10), 4(5)-germacradien-6α-7β-11β-olide, ratibinolide I, ratibinolide II, pedalitin, hispidulin, brine shrimp lethality test
Publication DOI: 10.1016/S0031-9422(00)90718-0Journal NLM ID: 0151434Publisher: Elsevier
Institutions: Laboratorio de Fitoquímica, Departmento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Coyoacán, México D.F. USA, Jardín Botánico, Instituto de Biología, Universidad Nacional Autónoma de México, Coyoacán, México D.F.USA
Found