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Structure type: oligomer
Trivial name: carumbelloside I
Compound class: saponin glycoside, glycoside
Contained glycoepitopes: IEDB_141806,IEDB_142488,IEDB_146664,IEDB_241101,IEDB_983931,SB_192

• Article ID: 10650
  Lin LJ, Lin LZ, Gil RR, Cordell GA, Ramesh M, Srilatha B, Reddy B, Venkata A, Rao AVNA "Pregnane glycosides from Caralluma umbellata" - Phytochemistry 35 (1994) 1549-1553
  

  From Caralluma umbellata, two new pregnane glycosides, named carumbelloside I and II, were isolated and their structures and stereochemistry were elucidated by a combination of NMR techniques as 3-O-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl-3β,14β-dihydroxypregn-5-en-20-one and 3-O-β-d-glucopyranosyl-3β,14β-dihydroxypregn-5-en-20-one. The ambiguous assignments were resolved through molecular modelling comparisons.

  molecular modelling, Structure determination, Asclepiadaceae, pregnane glycosides, Caralluma umbellata, carumbelloside I, carumbelloside II, NMR assignments, two-dimensional NMR techniques

  Publication DOI: 10.1016/S0031-9422(00)86892-2
  Journal NLM ID: 0151434
  Publisher: Elsevier
  Institutions: Program for Collaborative Research in Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, U.S.A., University College of Pharmaceutical Sciences, Kakatiya University, Warangal, A.P., India
  
   
  
  Caralluma umbellata
  CSDB ID 146272 (all data & tools)
• Article ID: 11762
  Ramesh M, Rao YN, Kumar MR, Venkata A, Rao NA, Prabhakar MC, Reddy BM "Antinociceptive and anti-inflammatory activity of carumbelloside I isolated from Caralluma umbellata" - Journal of Ethnopharmacology 68(1-3) (1999) 349-352
  

  The phytochemical study using Caralluma umbellata (Asclepiadaceae) whole plant allowed the isolation of a novel pregnane glycoside named carumbelloside I (3-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl-3β,14β-dihydroxypregn-5-en-20-one). Carumbelloside I was evaluated for both antinociceptive activity and anti-inflammatory activity. The antinociceptive activity was evaluated in mice using the writhing test method, while the anti-inflammatory activity was evaluated in rats using the paw edema test with carrageenin. Carumbelloside I has significant antinociceptive action. It has no anti-inflammatory activity.

  Asclepiadaceae, pregnane glycoside, Caralluma umbellata, antinociceptive activityAnti-inflammatory activity, carumbelloside-I, 3-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl-3β, 14β-dihydroxypregn-5-en-20-one

  NCBI PubMed ID: 10624901
  Publication DOI: 10.1016/S0378-8741(99)00122-1
  Journal NLM ID: 7903310
  Publisher: Limerick: Elsevier Sequoia
  Institutions: University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506 009, India, G. Pulla Reddy College of Pharmacy, Mehidipatnam, Hyderabad 500 028, India
  Methods: statistical analysis, anti-inflammation assay, antinociception assay, writhing test
  
   
  
  Caralluma umbellata
  CSDB ID 62807 (all data & tools)

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Structure type: monomer
Trivial name: carumbelloside II
Compound class: glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 10650
  Lin LJ, Lin LZ, Gil RR, Cordell GA, Ramesh M, Srilatha B, Reddy B, Venkata A, Rao AVNA "Pregnane glycosides from Caralluma umbellata" - Phytochemistry 35 (1994) 1549-1553
  

  From Caralluma umbellata, two new pregnane glycosides, named carumbelloside I and II, were isolated and their structures and stereochemistry were elucidated by a combination of NMR techniques as 3-O-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl-3β,14β-dihydroxypregn-5-en-20-one and 3-O-β-d-glucopyranosyl-3β,14β-dihydroxypregn-5-en-20-one. The ambiguous assignments were resolved through molecular modelling comparisons.

  molecular modelling, Structure determination, Asclepiadaceae, pregnane glycosides, Caralluma umbellata, carumbelloside I, carumbelloside II, NMR assignments, two-dimensional NMR techniques

  Publication DOI: 10.1016/S0031-9422(00)86892-2
  Journal NLM ID: 0151434
  Publisher: Elsevier
  Institutions: Program for Collaborative Research in Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, U.S.A., University College of Pharmaceutical Sciences, Kakatiya University, Warangal, A.P., India
  
   
  
  Caralluma umbellata
  CSDB ID 146273 (all data & tools)