Investigation of the roots of Patrinia scabra afforded two new iridolactones, patriscabrol and isopatriscabrol. Their structures have been established by extensive analysis of their NMR spectra and an X-ray crystallographic analysis of patriscabrol. Four monoglucosides of each iridolactone were also isolated together with an apioside of glucosidic patriscabrol.
roots, Patrinia scabra, Valerianaceae, iridolactones, patriscabrol, isopatriscabrol, patriscabrosides, isopatriscabrosides
NCBI PubMed ID: 7765627Publication DOI: 10.1016/0031-9422(94)85081-XJournal NLM ID: 0151434Publisher: Elsevier
Institutions: Faculty of Pharmaceutical Sciences, Nagasaki University, Japan, Analytical and Pharmaceutical Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd, Fukuoka, Japan, Faculty of Pharmaceutical Sciences, Shanxi Medical College, Taiyuan, China
Methods: 13C NMR, 1H NMR, EI-MS, IR, FAB-MS, X-ray, TLC, acid hydrolysis, HPLC, enzymatic digestion, CC, MPLC, acetylation analysis