Show legend Show as text

Structure type: oligomer ; 801 [M-H]-
C₄₁H₇₀O₁₅
Trivial name: vina-ginsenoside-R14
Compound class: saponin glycoside
Contained glycoepitopes: IEDB_114701,IEDB_142488,IEDB_146664,IEDB_167188,IEDB_174332,IEDB_983931,SB_192

• Article ID: 10720
  Nguyen MD, Kasai R, Ohtani K, Ito A, Nguyen TN, Yamasaki K, Tanaka O "Saponins from Vietnamese Ginseng, Panax vietnamensis Ha et Grushv. collected in central Vietnam. III" - Chemical and Pharmaceutical Bulletin 42 (1994) 634-640
  

  Five new dammarane saponins derived from four new aglycones were isolated from the rhizomes and roots of Panax vietnamensis HA et GRUSHV. On the basis of physicochemical and spectral evidence, the structures of these compounds were established as 6-O-β-D-glucopyranosyl 20(S),25-epoxydammarane-3β,6α,12β,24α-tetrol (1), 6-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranosyl 20(S),25-epoxydammarane- 3β,6α,12β,24α-tetrol (2), 6-O-β-D-glucopyranosyl dammarane-3β,6α,12β,20(S),24ξ,25-hexol (5), 3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl]-20-O-β-D-glucopyranosyl dammarane-3β,12β,20(S),24ξ,25-pentol (8) and 6-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranosyl 20(S),24(S)-epoxydammarane-3β,6α,12β,25ξ,26-pentol (10). The trivial names, vina-ginsenoside-R10,-R11,-R12,-R13 and -R14,respectively, were assigned to the new saponins.

  Vietnamese Ginseng, Panax vietnamensis, vina-ginsenoside-R10, vina-ginsenoside-R11, vina-ginsenoside-R12, vina-ginsenoside-R13, vina-ginsenoside-R14, new dammarane-type aglycone

  NCBI PubMed ID: 8004713
  Publication DOI: 10.1248/cpb.42.634
  Journal NLM ID: 0377775
  WWW link: http://ci.nii.ac.jp/naid/110003630993
  Publisher: Pharmaceutical Society Of Japan
  Institutions: The Science-Production Centre of Vietnamese Ginseng, Ho Chi Minh City University of Medicine and Pharmacy, Vietnam, Suzugamine Women's College, Japan, Vietnam, Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Hiroshima, Japan
  Methods: 13C NMR, 1H NMR, EI-MS, FAB-MS, partial acid hydrolysis, acid hydrolysis, HPLC, enzymatic digestion, CC, HR-FAB-MS
  
   
  
  Panax vietnamensis
  CSDB ID 120360 (all data & tools)

Show legend Show as text

Structure type: oligomer
Trivial name: vina-ginsenoside R14
Compound class: glycoside, triterpenoid glycoside
Contained glycoepitopes: IEDB_114701,IEDB_142488,IEDB_146664,IEDB_167188,IEDB_174332,IEDB_983931,SB_192

• Article ID: 12848
  Yamasaki K "Bioactive saponins in Vietnamese ginseng, Panax vietnamensis" - Pharmaceutical Biology (2000) 16-24
  

  Vietnamese ginseng, Panax vietnamensis was recently found in central Vietnam, and regarded as a new botanical species. It was used in traditional folk medicine in hill tribes for the purpose of anti-fatigue and life saving. From the rhizome and root of this plant, 37 saponins including 14 new compounds were isolated. Some of them were common to other Panax spp., but the general yields in this species were very high. Among them, an ocotillol-type saponin majonoside-R2 (MR2) was remarkable in its yield (5.3%). Structural features of new saponins were briefly introduced. The biological effects of these saponins were studied in two ways, anti-stress effect and anti-tumor promoting effect; both activities were based upon the traditional usage of this crude drug. In psychologically stressed mice, the saponin fraction of Vietnamese ginseng significantly reduced stress-related disorders (reducing sleeping time, formation of gastric lesions) and MR2 was responsible for this effect. A possible mechanism for this effect was proposed. MR2 exhibited a significant inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induced by the tumor promoter phorbol acetate. MR2 also showed potent anti-tumor-promoting activity on mouse skin and hepatic tumors.

  Vietnamese Ginseng, Panax vietnamensis, dammarane saponin, majonoside-R2, cancer chemoprevention, adaptogen, antistress, anti-tumor promotion, ocotillol, vinaginsenoside

  NCBI PubMed ID: 23531134
  Publication DOI: 10.1076/phbi.38.6.16.5956
  Journal NLM ID: 9812552
  Publisher: Lisse, the Netherlands: Swets & Zeitlinger
  Correspondence: yamasaki@pharm.hiroshima-u.ac.jp
  Institutions: Institute of Pharmaceutical Sciences, Faculty of Medicine, Hiroshima University, Hiroshima, Japan
  
   
  
  Panax vietnamensis
  CSDB ID 68722 (all data & tools)