A new spirostanol saponin and two new furostanol saponins were isolated from the fresh bulbs of Allium giganteum together with several known saponins. The structures of the new compounds were determined on the basis of spectroscopic data, the products formed on hydrolysis and by comparing their properties with those of known compounds. The isolated saponins and their derivatives were evaluated for inhibitory activity by examining their action on cAMP phosphodiesterase as a primary screening test to identify new medicinal agents.
Liliaceae, steroidal saponin, furostanol saponin, spirostanol saponin, Allium giganteum, cAMP phosphodiesterase inhibition
Publication DOI: 10.1248/cpb.42.710Journal NLM ID: 0377775WWW link: http://ci.nii.ac.jp/naid/110003631011Publisher: Pharmaceutical Society Of Japan
Institutions: Tokyo College of Pharmacy, Tokyo, Japan, School of Pharmaceutical Sciences, Toho University, Japan
Methods: 13C NMR, 1H NMR, IR, FAB-MS, TLC, enzymatic digestion, CC, biological assay, acetylation analysis, alkaline methanolysis