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Structure type: oligomer ; 924 [M]-
C₄₇H₇₂O₁₈
Compound class: saponin glycoside
Contained glycoepitopes: IEDB_139965,IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 10722
  Mikaki Y, Nikaido T, Matsumoto K, Sashida Y, Ohmoto T "New steroidal saponins from the bulbs of Allium giganteum exhibiting potent inhibition of cAMP phosphodiesterase activity" - Chemical and Pharmaceutical Bulletin 42 (1994) 710-714
  

  A new spirostanol saponin and two new furostanol saponins were isolated from the fresh bulbs of Allium giganteum together with several known saponins. The structures of the new compounds were determined on the basis of spectroscopic data, the products formed on hydrolysis and by comparing their properties with those of known compounds. The isolated saponins and their derivatives were evaluated for inhibitory activity by examining their action on cAMP phosphodiesterase as a primary screening test to identify new medicinal agents.

  Liliaceae, steroidal saponin, furostanol saponin, spirostanol saponin, Allium giganteum, cAMP phosphodiesterase inhibition

  Publication DOI: 10.1248/cpb.42.710
  Journal NLM ID: 0377775
  WWW link: http://ci.nii.ac.jp/naid/110003631011
  Publisher: Pharmaceutical Society Of Japan
  Institutions: Tokyo College of Pharmacy, Tokyo, Japan, School of Pharmaceutical Sciences, Toho University, Japan
  Methods: 13C NMR, 1H NMR, IR, FAB-MS, TLC, enzymatic digestion, CC, biological assay, acetylation analysis, alkaline methanolysis
  
   
  
  Allium giganteum
  CSDB ID 270374 (all data & tools)

Show legend Show as text

Structure type: oligomer ; 862 [M]-
C₄₂H₇₀O₁₈
Compound class: saponin glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 10722
  Mikaki Y, Nikaido T, Matsumoto K, Sashida Y, Ohmoto T "New steroidal saponins from the bulbs of Allium giganteum exhibiting potent inhibition of cAMP phosphodiesterase activity" - Chemical and Pharmaceutical Bulletin 42 (1994) 710-714
  

  A new spirostanol saponin and two new furostanol saponins were isolated from the fresh bulbs of Allium giganteum together with several known saponins. The structures of the new compounds were determined on the basis of spectroscopic data, the products formed on hydrolysis and by comparing their properties with those of known compounds. The isolated saponins and their derivatives were evaluated for inhibitory activity by examining their action on cAMP phosphodiesterase as a primary screening test to identify new medicinal agents.

  Liliaceae, steroidal saponin, furostanol saponin, spirostanol saponin, Allium giganteum, cAMP phosphodiesterase inhibition

  Publication DOI: 10.1248/cpb.42.710
  Journal NLM ID: 0377775
  WWW link: http://ci.nii.ac.jp/naid/110003631011
  Publisher: Pharmaceutical Society Of Japan
  Institutions: Tokyo College of Pharmacy, Tokyo, Japan, School of Pharmaceutical Sciences, Toho University, Japan
  Methods: 13C NMR, 1H NMR, IR, FAB-MS, TLC, enzymatic digestion, CC, biological assay, acetylation analysis, alkaline methanolysis
  
   
  
  Allium giganteum
  CSDB ID 270375 (all data & tools)