Two new glycosides have been isolated from the MeOH extract of the stem wood and stem bark of an Ecuadorian plant Chamaedorea linearis, and their structures have been determined by spectroscopic means and X-ray analysis of the aglycone to be 1-O-[β-L-fucopyranosyl-(4'-sulfate)]-25R,5α-spirostane-1β,3β-diol [1]) and 1-O-[β-L-fucopyranosyl-(4'-sulfate)]-25R,5α-spirostane-1α,3β-diol [2]. These compounds were identified in a screen for inhibitors of recombinational DNA repair. Cytotoxic activity was also demonstrated.
NCBI PubMed ID: 8254345Publication DOI: 10.1021/np50099a003Journal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Institutions: Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939
Methods: 13C NMR, 1H NMR, FAB-MS, TLC, acid hydrolysis, bioassay
Found