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Structure type: oligomer ; 803 [M+Na]+
C₄₁H₆₄O₁₄
Trivial name: scoparianoside A
Compound class: saponin glycoside
Contained glycoepitopes: IEDB_114701,IEDB_115136,IEDB_140630,IEDB_167188,IEDB_174332,IEDB_423153

• Article ID: 11108
  Yoshikawa M, Shimada H, Morikawa T, Yoshizumi S, Matsumura N, Murakami T, Matsuda H, Hori K, Yamahara J "Medicinal foodstuffs. VII. On the saponin constituents with glucose and alcohol absorption-inhibitory activity from a food garnish "Tonburi", the fruit of Japanese Kochia scoparia (L.) Schrad.: structures of scoparianosides A, B, and C." - Chemical and Pharmaceutical Bulletin 45(8) (1997) 1300-1305
  

  The methanolic extract of a food garnish "Tonburi", the fruit of Japanese kochia scoparia (L.) Schrad. (Chenopodiaceae), was found to inhibit the increase in serum glucose-loaded rats. Through bioassay-guided separation, momordin Ic and its 2'-O-β-D-glucopyranoside were isolated as the active principles from this medicinal foodstuff together with three new saponins named scoparianosides A, B, and C. The structures of scoparianosides A, B, and C were elucidated on the basis of chemical and physicochemical evidence as 3β,22α-dihydroxyolean-12en-28-oic acid (22α-hydroxyoleanolic acid), 3-O-β-D-xylopyranosyl(1→3)-β-D-glucopyranosiduronic acid, 3β-hydroxyolean -18-en-28-oic acid (morolic acid), 3-O-β-D-xylopyranosyl(1→3)-β-D-glucopyranosiduronic acid, and 3β-hydroxyolean-13(18)-en-28-oic acid, 3-O-β-D-xylopyranoxyl(1→3)-β-D-glucopyranosiduronic acid. Momordin Ic and its 2'-O-β-D-glucopyranoside, both of which are the principal saponin constituents of this medicinal foodstuffs, were found to potently inhibit glucose and ethanol absorption in rats.

  medicinal foodstuff, alcohol absorption inhibitor, glucose absorption inhibitor, scoparianoside, Kochia scoparia, Tonburi

  NCBI PubMed ID: 9301029
  Publication DOI: 10.1248/cpb.45.1300
  Journal NLM ID: 0377775
  Publisher: Pharmaceutical Society Of Japan
  Institutions: Kyoto Pharmaceutical University, Kyoto, Japan
  Methods: 13C NMR, 1H NMR, IR, FAB-MS, sugar analysis, enzymatic hydrolysis, acid hydrolysis, biological assays, HPLC
  
   
  
  Kochia scoparia
  CSDB ID 60147 (all data & tools)

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Structure type: monomer ; 671 [M-Na]+
C₃₆H₅₆NaO₁₀
Trivial name: kochianoside I
Compound class: saponin glycoside
Contained glycoepitopes: IEDB_115136,IEDB_140630,IEDB_423153

• Article ID: 11126
  Yoshikawa M, Dai Y, Shimada H, Morikawa T, Matsumura N, Yoshizumi S, Matsuda H, Kubo M "Studies on Kochiae Fructus. II. On the saponin constituents from the fruit of Chinese Kochia scoparia (Chenopodiaceae): Chemical structures of kochianosides I, II, III, and IV" - Chemical and Pharmaceutical Bulletin 45(6) (1997) 1052-1055
  

  Four new saponins called kochianosides I, II, III, and IV were isolated from the glycosidic fraction of the fruit of Chinese Kochia scoparia, which has exhibited an antipruritogenic effect, together with eight known saponins. The structures of kochianosides I, II, III, and IV were characterized on the basis of physicochemical evidence as 22α-hydroxyoleanolic acid 3-O-β-D-glucopyranosiduronic acid, morolic acid 3-O-[β-D-glucopyranosyl(1→2)][β-D-xylopyranosyl(1→3)]-β-D-glucopyranosiduronic acid, 3β,12α-dihydroxyolean-28,13α-olide 3-O-β-D-xylopyranosyl(1→3)-β-D-glucopyranosiduronic acid, and betulinic acid 3-O-β-D-xylopyranosyl(1→3)-β-D-glucopyranosiduronic acid, respectively.

  Chenopodiaceae, saponin, Kochia scoparia, kochianoside, antipruritogenic effect, 22α-hydroxyoleanolic acid

  Publication DOI: 10.1248/cpb.45.1052
  Journal NLM ID: 0377775
  Publisher: Pharmaceutical Society Of Japan
  Institutions: Kyoto Pharmaceutical University, Kyoto, Japan
  Methods: 13C NMR, 1H NMR, IR, FAB-MS, chemical methods, HPLC, extraction
  
   
  
  Kochia scoparia
  CSDB ID 60231 (all data & tools)