From the seeds of Tabernaemontana cymosa ( = T. psychotrifolia) 17 indole alkaloids and six lignan glucosides were isolated, besides triacylglycerols, 9,12-octadecadienoic acid, lupeol, (+)-lyoniresinol, obtusifoliol, sweroside and a glucoside of 3-O-methylgallic acid. 9-(β-d-Glucopyranosyloxy)-tetrahydroalstonine, 9-(b-D-glucopyranosyloxy)tetrahydroalstonine,lignan glueosides,(+)-5,5'-dimethoxy-9-O-(b-D-glucopyranosyl)lariciresinol, (-)-2a-O-(b-D-glucopyranosyl)lyoniresinol, and 3-O-(b-D-glucopyranosyl)-5-O-methylgallic acid are described for the first time. Structural determination is based on spectroscopic studies and/or on comparison with authentic compounds. Some of the isolated substances exhibited significant antifungal and/or cytotoxic effects
5, seeds, Apocynaceae, abernaemontana cymosa (= T. psychotrifolia), indole alkaloids, 9-(b-D-glucopyranosyloxy)tetrahydroalstonine, lignan glueosides, 5'-dimethoxy-9-O-(b-D-glucopyranosyl)lariciresinol, 2a-O-(b-D-glucopyranosyl)lyoniresinol, 3-O-(b-D-glucopyranosyl)-5-O-methylgallic acid
Publication DOI: 10.1016/S0031-9422(96)00645-0Journal NLM ID: 0151434Publisher: Elsevier
Institutions: Institute of Pharmacy and Food Chemistry, Department of Pharmaceutical Chemistry, University of Erlangen, D-91052 Erlangen, Germany
Methods: 13C NMR, 1H NMR, IR, sugar analysis, TLC, ESI-MS, GC, chemical methods, HPLC, UV, extraction, CD