Four new flavonol 7-O-glycosides 1-4 and a new chalcone ester glycoside 5 have been isolated from the leaves of Bidens leucantha along with four known chalcone ester glycosides 6-9. Their structures were elucidated using a combination of spectroscopic techniques. The in vitro anti-HIV activity of all the compounds was tested as part of our screening of potential anti-AIDS agents from medicinal plants. Although none of the flavonol glycosides was active, a moderate inhibitory effect on viral replication was exerted by chalcone ester glycoside 9.
NCBI PubMed ID: 9090869Publication DOI: 10.1021/np960572qJournal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Institutions: Centro Interdipartimentale di Chimica, Biologia e Technologie Farmaceutiche, Università degli Studi di Salerno, Italy
Methods: 13C NMR, 1H NMR, NMR-2D, FAB-MS, sugar analysis, TLC, chemical methods, HPLC, extraction, antiviral assay
Found