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Structure type: monomer ; 310.1500 [M+H]+
C₁₂H₂₄O₈N
Trivial name: alkaloide
Compound class: saponin glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 11168
  Kato A, Asano N, Kizu H, Matsui K, Watson AA, Nash RJ "Fagomine isomers and glycosides from Xanthocercis zambesiaca" - Journal of Natural Products 60(3) (1997) 312-314
  

  50% aqueous MeOH extracts from the leaves and roots of Xanthocercis zambesiaca (Leguminosae) were subjected to various ion-exchange column chromatographic steps to give fagomine (1), 3-epi-fagomine (2), 3,4-di-epi-fagomine (3), 3-O-β-D-glucopyranosylfagomine (4), and 4-0-β-D-glucopyranosylfagomine (5). Their structures were determined by spectroscopic analyses, particularly by extensive 1D and 2D NMR studies. Compounds 3 and 4 are new natural products. Compound 1 is a good inhibitor of isomaltase and certain α- and β-galactosidases. Whereas 2 is a more potent inhibitor of isomaltase and β-galactosidases than 1, it does not inhibit α-galactosidase. Compounds 3-5 exhibited no significant inhibition against the glycosidases used.

  Publication DOI: 10.1021/np960646y
  Journal NLM ID: 7906882
  Publisher: American Society of Pharmacognosy
  Institutions: Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa 920-11, Japan
  Methods: 13C NMR, 1H NMR, NMR-2D, sugar analysis, chemical methods, NMR-1D, extraction, HPTLC, HR-FAB-MS
  
   
  
  Xanthocercis zambesiaca
  CSDB ID 60512 (all data & tools)

Show legend Show as text

Structure type: monomer ; 310.1504 [M+H]+
C₁₂H₂₄O₈N
Trivial name: alkaloide
Compound class: saponin glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 11168
  Kato A, Asano N, Kizu H, Matsui K, Watson AA, Nash RJ "Fagomine isomers and glycosides from Xanthocercis zambesiaca" - Journal of Natural Products 60(3) (1997) 312-314
  

  50% aqueous MeOH extracts from the leaves and roots of Xanthocercis zambesiaca (Leguminosae) were subjected to various ion-exchange column chromatographic steps to give fagomine (1), 3-epi-fagomine (2), 3,4-di-epi-fagomine (3), 3-O-β-D-glucopyranosylfagomine (4), and 4-0-β-D-glucopyranosylfagomine (5). Their structures were determined by spectroscopic analyses, particularly by extensive 1D and 2D NMR studies. Compounds 3 and 4 are new natural products. Compound 1 is a good inhibitor of isomaltase and certain α- and β-galactosidases. Whereas 2 is a more potent inhibitor of isomaltase and β-galactosidases than 1, it does not inhibit α-galactosidase. Compounds 3-5 exhibited no significant inhibition against the glycosidases used.

  Publication DOI: 10.1021/np960646y
  Journal NLM ID: 7906882
  Publisher: American Society of Pharmacognosy
  Institutions: Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa 920-11, Japan
  Methods: 13C NMR, 1H NMR, NMR-2D, sugar analysis, chemical methods, NMR-1D, extraction, HPTLC, HR-FAB-MS
  
   
  
  Xanthocercis zambesiaca
  CSDB ID 60513 (all data & tools)