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Kogan G, Uhrin D, Brisson J, Paoletti LC, Blodgett AE, Kasper DL, Jennings HJ
Structural and immunochemical characterization of the type VIII group B Streptococcus capsular polysaccharide
Journal of Biological Chemistry 271(15) (1996)
8786-8790
a-Neup5Ac-(2-3)-+
|
-4)-b-D-Galp-(1-4)-b-L-Rhap-(1-4)-b-D-Glcp-(1- |
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Streptococcus sp. B VIII
(Ancestor NCBI TaxID 1319,
species name lookup)
Taxonomic group: bacteria / Firmicutes
(Phylum: Firmicutes)
Associated disease: infection due to Streptococcus [ICD11:
XN3NM 
]
The structure was elucidated in this paperNCBI PubMed ID: 8621515Journal NLM ID: 2985121RPublisher: Baltimore, MD: American Society for Biochemistry and Molecular Biology
Institutions: Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada
The type VIII capsular polysaccharide has been isolated and purified from a newly described strain of group B Streptococcus which is a leading cause of sepsis and neonatal meningitis in Japan. The polysaccharide contains D-glucose, D-galactose, L-rhamnose, and sialic acid in the molar ratio 1:1:1:1. By means of high resolution 1H nuclear magnetic resonance (1H NMR), 13C NMR, and homo- and heterocorrelated NMR, the repeating unit structure of the type VIII polysaccharide was delineated as the following, [formula: see text] Enzymatic studies established this polysaccharide as the first from which sialic acid, linked to a branched β-D-galactopyranosyl residue, is known to be removed by bacterial neuraminidase.
NMR, structural, capsular, characterization, polysaccharide, Streptococcus, capsular polysaccharide, group, type, group B Streptococcus, NMR spectroscopy, spectroscopy, elucidation, immunochemical, N-acetylneuraminic acid
Structure type: polymer chemical repeating unit
Location inside paper: Fig.2
Compound class: CPS
Contained glycoepitopes: IEDB_136044,IEDB_136794,IEDB_137472,IEDB_141794,IEDB_142488,IEDB_146100,IEDB_146664,IEDB_146668,IEDB_149174,IEDB_150933,IEDB_190606,IEDB_225177,IEDB_885823,IEDB_983931,SB_116,SB_165,SB_166,SB_170,SB_171,SB_172,SB_187,SB_192,SB_195,SB_39,SB_68,SB_7,SB_84,SB_88
Methods: NMR, enzymatic desialylation
Biological activity: serological data
Enzymes that release or process the structure: neuraminidase
Comments, role: published polymerization frame was shifted for conformity with other records.
Related record ID(s): 2962
NCBI Taxonomy refs (TaxIDs): 1319Reference(s) to other database(s): GTC:G62462RE, GlycomeDB:
27674
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There is only one chemically distinct structure:
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Kogan G, Uhrin D, Brisson J, Paoletti LC, Blodgett AE, Kasper DL, Jennings HJ
Structural and immunochemical characterization of the type VIII group B Streptococcus capsular polysaccharide
Journal of Biological Chemistry 271(15) (1996)
8786-8790
Streptococcus sp. B VIII
(Ancestor NCBI TaxID 1319,
species name lookup)
Taxonomic group: bacteria / Firmicutes
(Phylum: Firmicutes)
Associated disease: infection due to Streptococcus [ICD11:
XN3NM 
]
The structure was elucidated in this paperNCBI PubMed ID: 8621515Journal NLM ID: 2985121RPublisher: Baltimore, MD: American Society for Biochemistry and Molecular Biology
Institutions: Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada
The type VIII capsular polysaccharide has been isolated and purified from a newly described strain of group B Streptococcus which is a leading cause of sepsis and neonatal meningitis in Japan. The polysaccharide contains D-glucose, D-galactose, L-rhamnose, and sialic acid in the molar ratio 1:1:1:1. By means of high resolution 1H nuclear magnetic resonance (1H NMR), 13C NMR, and homo- and heterocorrelated NMR, the repeating unit structure of the type VIII polysaccharide was delineated as the following, [formula: see text] Enzymatic studies established this polysaccharide as the first from which sialic acid, linked to a branched β-D-galactopyranosyl residue, is known to be removed by bacterial neuraminidase.
NMR, structural, capsular, characterization, polysaccharide, Streptococcus, capsular polysaccharide, group, type, group B Streptococcus, NMR spectroscopy, spectroscopy, elucidation, immunochemical, N-acetylneuraminic acid
Structure type: polymer chemical repeating unit
Location inside paper: Fig.2
Trivial name: desialylated polysaccharide
Contained glycoepitopes: IEDB_136044,IEDB_137472,IEDB_141794,IEDB_142488,IEDB_146664,IEDB_146668,IEDB_190606,IEDB_225177,IEDB_885823,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_7,SB_88
Methods: NMR, enzymatic desialylation
Related record ID(s): 2844
NCBI Taxonomy refs (TaxIDs): 1319Reference(s) to other database(s): GTC:G47684IA, GlycomeDB:
25822
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There is only one chemically distinct structure:
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