Biologically active compounds in leaves of Lycium chinense (Lycii Folium) were examined to develop the effective use of this plant as a health food. The methanol extract of Lycii Folium exhibited antimicrobial activities, and one of the active compounds was identified as lyciumoside I (1) which is a characteristic component of Lycium chinense. Furthermore, the methanol extract of Lycii Folium inhibited the growth of Helicobacter pylori. The active component against H. pylori was also identified as 1. Quantitative analyses revealed that 1 was extracted into Kuko tea in high concentration. The hydrolysis products of 1 were also assayed for antimicrobial activity to study their structure-activity relationship.
Helicobacter pylori, antimicrobial activity, Solanaceae, MIC, Lycium chinense, Lycii Folium, acyclic diterpene glycosides, lyciumoside
Publication DOI: 10.3358/shokueishi.39.6_399Journal NLM ID: 0142214Publisher: Tokyo: Food Hygienic Society
Institutions: Faculty of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan, Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Hiroshima, Japan, Hiroshima Prefectural Institute of Public Health and Environment, Hiroshima, Japan
Methods: FAB-MS, TLC, enzymatic hydrolysis, HPLC, extraction, CC, antimicrobial assay
Found