A crude aqueous extract of Mentzelia chilensis GAY (Loasaceae), the ethyl acetate extraction thereof as well as the molecular weight fraction <1000 Dalton obtained by ultrafiltration showed antiinflammatory activity on carrageenin induced rat paw oedema. Bioassay guided isolation led to the iridoid glycoside mentzeloside (syn. deutzioside) as an active principle. Mentzeloside showed a marked and significant dose dependent inhibitory activity on carrageenin induced rat paw oedema with an ED50 Of 40.4 μg/kg.
antiinflammatory activity, Iridoids, Mentzelia chilensis, Mentzelia fendleriana, anguarate, mentzeloside, deutzioside
Publication DOI: 10.1002/(SICI)1099-1573(199806)12:4<275::AID-PTR295>3.0.CO;2-IJournal NLM ID: 8904486Publisher: Chichester: Wiley
Institutions: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, US, University of California Los Angeles LA Biomed, Torrance, US, University of Canterbury, Sch Phys & Chem Sci, Christchurch, New Zealand, ADT Pharmaceut LLC, Orange Beach, AL, USA
Methods: 13C NMR, 1H NMR, EI-MS, TLC, HPLC, UV, extraction, CC, ultrfiltration
Found