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Structure type: monomer
Trivial name: aloin A, aloin A, aloin B
Compound class: glycoside

• Article ID: 11478
  Rauwald HW "Herbal laxatives: influence of anthrones-anthraquinones on energy metabolism and ion transport in a model system" - ACS Symposium Series 691 (1998) 97-116
  

  There is good evidence that anthrones/anthraquinones, known as active metabolites of emodin-type O- and C-glycosyl compounds which are found in many plant laxatives, influence the ion transport across colon cells, although the target transport systems have not yet been elucidated. There are various contradictory results used to explain the laxative action of these drugs. To elucidate this problem we tested 25 different anthrone/anthraquinone metabolites of plant drugs for their influence on different ion transport systems in Ehrlich cells as a model system. Comparing the laxative potency of these substances with their influence on the different ion transport systems involved in transepithelial ion transport makes it possible to exclude some transport processes as primary targets of the drugs. The following results were found: (1) Na+-K+-ZCl- cotransport was not inhibited by any of the substances tested. (2) Na+/K+-ATPase (pump) was inhibited by those 1,8-dihydroxyanthrones/anthraquinones that bear an additional phenolic hydroxyl group. This inhibition is indirect by interference with oxidative ATP production. However, there is no correlation to laxative action. (3) Cation channels were not influenced by these drugs. (4) Cl- -channels were inhibited significantly by those drugs that also show a laxative action. It is not clear, whether this effect is due to a direct interference with the channels or indirectly due to influences on the signal cascade triggering the transport. These results make it very likely that inhibition of Cl--channels is the primary action responsible for the laxative effect. Interference with oxidative ATP production as an additional effect may explain the known synergistic action described for the :combination of different anthrones/anthraquinones or anthranoid drugs, respectively.

  herbal drugs, organic sources, laxatives

  Publication DOI: 10.1021/bk-1998-0691.ch009
  Journal NLM ID: 100961485
  Publisher: American Chemical Society
  Institutions: Department of Pharmacy, Pharmaceutical Biology, University of Leipzig, Leipzig, Germany
  
   
  
  Aloe
  CSDB ID 61962 (all data & tools)
• Article ID: 12784
  van Heerden FR, Viljoen AM, van Wyk B-E "6'-O-Coumaroylaloesin from Aloe castanea - a taxonomic marker for Aloe section Anguialoe" - Phytochemistry 55(2) (2000) 117-120
  

  The structure of 6′-O-coumaroylaloesin [2-acetonyl-8-(6-O-coumaroyl-β-d-glucopyranosyl)-7-hydroxy-5-methylchromone], a mono-ester chromone derivative in which only the 6-position of the glucosyl moiety is esterified, was determined by spectroscopic methods. The compound is a unique chemotaxonomic character restricted to the six species in Aloe section Anguialoe.

  Aloe castanea; Anguialoe; Asphodelaceae; chromone; 6'-O-coumaroylaloesin; chemotaxonom

  NCBI PubMed ID: 11065286
  Publication DOI: 10.1016/s0031-9422(00)00252-1
  Journal NLM ID: 0151434
  Publisher: Elsevier
  Correspondence: van Heerden FR
  Institutions: Department of Chemistry and Biochemistry, Rand Afrikaans University, Auckland Park, South Africa, Department of Botany, Rand Afrikaans University, Auckland Park, South Africa
  Methods: 13C NMR, 1H NMR, IR, TLC, HPLC, UV, extraction, optical rotation measurement, melting point determination, HR-FAB-MS
  
   
  
  Aloe alooides, Aloe castanea, Aloe dolomitica, Aloe spicata, Aloe tauri
  CSDB ID 68315 (all data & tools)