Show legend Show as text

Structure type: monomer
Compound class: glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 11487
  Matsuda H, Ishikado A, Nishida N, Ninomiya K, Fujiwara H, Kobayashi Y, Yoshikawa M "Hepatoprotective, superoxide scavenging, and antioxidative activities of aromatic constituents from the bark of Betula platyphylla var. japonica" - Bioorganic and Medicinal Chemistry Letters 8(21) (1998) 2939-2944
  

  The 50% aqueous methanolic extract from the bark of Betula platyphylla SUKATCHEV var. japonica (MIQ) HARA was found to show potent inhibitory activity on the liver-injury induced by CCl4 or D-galactosamine (D- GalN)/lipopolysaccharide as well as O2- scavenging and antioxidative activities. From the 50% aqueous methanolic extract, two new diarylheptanoids named betulaplatosides Ia (1) and Ib (2) and a new arylbutanoid named betulaplatoside II (3) were isolated together with seventeen known aromatic constituents. 1, 2, and two known diarylheptanoids [(5S)-5-hydroxy-1,7-bis- (4-hydroxyphenyl)-3-heptanone 5-O-β-D-apiofurano-syl-(1→6)-β-D- glucopyranoside (6) and aceroside VIII (7)] showed protective activity against D-GaIN-induced cytotoxicity in primary cultured rat hepatocytes. Furthermore, several aromatic constituents exhibited potent O2- scavenging and antioxidative activities.

  mice, Animals, Plant Extracts, Antioxidants, free radical scavengers, liver, Betula platyphylla, Betula

  NCBI PubMed ID: 9873651
  Publication DOI: 10.1016/S0960-894X(98)00528-9
  Journal NLM ID: 9107377
  Publisher: Elsevier
  Institutions: Kyoto Pharmaceutical University, Kyoto, Japan, Sunstar Inc., Takatsuki, Japan
  Methods: 13C NMR, 1H NMR, IR, FAB-MS, enzymatic hydrolysis, acid hydrolysis, GLC, biological assays, HPLC, UV, extraction, optical rotation measurement, CC, antioxidant activities, HMBC, radical scavenging assay, NaNH4 reduction, opitcal rotation measurement, enzymatic hidrolysis
  
   
  
  Betula platyphylla var. japonica
  CSDB ID 62113 (all data & tools)

Show legend Show as text

Structure type: monomer
Compound class: glycoside
Contained glycoepitopes: IEDB_114701,IEDB_167188,IEDB_174332

• Article ID: 11981
  Adnyana IK, Tezuka Y, Banskota AH, Tran KQ, Kadot S "Hepatoprotective constituents of the seeds of Combretum quadrangulare" - Biological and Pharmaceutical Bulletin 23(11) (2000) 1328-1332
  

  Hepatoprotective effect of MeOH, MeOH-H2O (1:1) and H2O extracts of Combretum quadrangulare seeds were examined on D-galactosamine (D-GalN)/tumor necrosis factor-α(TNF-α)-induced cell death in primary cultured mouse hepatocytes. The MeOH extract showed the strongest inhibitory effect on D-GalN/TNF-α-induced cell death (IC50, 56.4 μg/ml). Moreover, the MeOH extract also significantly lowered the serum glutamic pyruvic transaminase (sGPT) level on D-GalN/lipopolysaccharide (LPS)-induced liver injury in mice. Bioguided separation of the MeOH extract led to the isolation of 38 compounds of various classes including triterpene glucosides, lignans and catechin derivatives. Among the isolated triterpene glucosides, lupane-type (1-3; IC50, 63.1, 59.8 and 76.2 μM, respectively) and ursane-type (11, mixture of 12 and 14; IC50, 30.2 and 34.6 μM, respectively) compounds exhibited strong hepatoprotective activity. 1-O-Galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-β-D-glucose (26; IC50, 7.2 μM), methyl gallate (28; IC50, 19.9 μM), and (-)-epicatechin (31; IC50, 71.2 μM) also had a potent hepatoprotective effect on D-GalN/TNF-α-induced cell death in primary cultured mouse hepatocytes.

  hepatoprotective effect, catechin, Combretum quadrangulare, triterpene glucoside, Vietnamese medicinal plant, 1-O-Galloyl-6-O-(4-hydroxy-3, 5-dimethoxy)benzoyl-β-D-glucose

  NCBI PubMed ID: 11085361
  Publication DOI: 10.1248/bpb.23.1328
  Journal NLM ID: 9311984
  Publisher: Pharmaceutical Society of Japan
  Correspondence: kadota@ms.toyama-mpu.ac.jp
  Institutions: Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan, National University Ho Chi Minh City, Ho Chi Minh City, Vietnam
  Methods: biological assays, extraction, CC, cell viability assay, MTT, hepatoprotective activity assay
  
   
  
  Combretum quadrangulare
  CSDB ID 64652 (all data & tools)