Show legend Show as text

Structure type: monomer
Trivial name: woorenoside V
Compound class: glycoside
Contained glycoepitopes: IEDB_115136,IEDB_140630,IEDB_423153

• Article ID: 11499
  Cho J, Park J, Yoo E, Yoshikawa K, Baik K, Lee J, Park M "Inhibitory effect of lignans from the rhizomes of Coptis japonica var. dissecta on tumor necrosis factor-α production in lipopolysaccharide-stimulated RAW264.7 cells" - Archives of Pharmacal Research 21(1) (1998) 12-16
  

  The inhibitory effect of 10 lignan constituents isolated from the rhizomes of Coptis japonica var. dissecta on tumor necrosis factor (TNF)-α production in lipopolysaccharide (LPS)-stimulated macrophage cell line (RAW264.7 cells) has been studied. Among them, pinoresinol, woorenoside-V and lariciressinol glycoside showed significant inhibitory activities in the range from 37% to 55% at the concentration of 25 μg/ml. The results are first report that the lignans isolated from Coptis japonica inhibit TNF-α production, and suggest that the lignan components may partly participate in antiinflammatory and antiallergic effect of Coptis japonica through the inhibition of TNF-α production.

  LPS, ELISA, TNF-α, pinoresinol, lignan, Coptis japonica, Lariciresinol glycoside, RAW264.7, Woorenoside

  NCBI PubMed ID: 9875508
  Publication DOI: 10.1007/BF03216746
  Journal NLM ID: 8000036
  Publisher: Pharmaceutical Society of Korea
  Institutions: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan, R and D Center, Daewoong Pharm. Co. Ltd., Sungnam, Kyunggi-Do, South Korea
  Methods: ELISA, extraction, CC, TNF-a assay
  
   
  
  Coptis japonica var. dissecta
  CSDB ID 62039 (all data & tools)

Show legend Show as text

Structure type: monomer
Compound class: glycoside, lignan
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 12133
  Deyama T, Ikawa T, Kitagawa S, Nishibe S "The constituents of Eucommia ulmoides OLIV. VI. Isolation of a new sesquilignan and neolignan glycosides" - Chemical and Pharmaceutical Bulletin 35(5) (1987) 1803-1807
  

  A new sesquilignan glycoside, syringylglycerol-β-syringaresinol ether 4'',4'''-di-Ο-β-D-glucopyranoside (1), and a new neolignan glycoside, dehydrodiconiferyl alcohol 4,γ'-di-Ο-β-D-glucopyranoside (2), were isolated from the bark of Eucommia ulmoides Ouv. (Eucommiaceae), together with a known neolignan glycoside, citrusin B (3). Their structures were determined on the basis of chemical evidence and spectroscopic analyses.

  13C-NMR, Eucommia ulmoides, lignan, sesquilignan, neolignan, dihydrobenzofuran, syringylglycerol-β-syringaresinol ether 4'', 4'''-di-Ο-β-D-glucopyranoside, dehydrodiconiferyl alcohol 4, γ'-di-Ο-β-D-glucopyranoside

  Publication DOI: 10.1248/cpb.35.1803
  Journal NLM ID: 0377775
  Publisher: Pharmaceutical Society Of Japan
  Institutions: Faculty of Pharmaceutical Sciences, Higashi Nippon Gakuen University, Ishikari-Tobetsu, Japan, Central Research Laboratories, Yomeishu Seizo, Co., Ltd., Minowa-cho, Japan
  Methods: 13C NMR, 1H NMR, EI-MS, gel filtration, IR, TLC, GC, HPLC, UV, enzymatic digestion, extraction, optical rotation measurement, acetylation, CC, FD-MS, melting point determination, derivatization, evaporation
  
   
  
  Eucommia ulmoides
  CSDB ID 65321 (all data & tools)