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Structure type: oligomer
C₅₆H₉₁O₂₉
Trivial name: yayoisaponin B
Compound class: triterpenoid glycoside
Contained glycoepitopes: IEDB_114701,IEDB_136044,IEDB_137472,IEDB_140628,IEDB_141794,IEDB_142488,IEDB_146664,IEDB_153543,IEDB_167188,IEDB_174332,IEDB_190606,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_7,SB_88

• Article ID: 11537
  Sata N, Matsunaga S, Fusetani N, Nishikawa H, Takamura S, Saito T "New antifungal and cytotoxic steroidal saponins from the bulbs of an elephant garlic mutant" - Bioscience, Biotechnology, and Biochemistry 62(10) (1998) 1904-1911
  

  Saponins in bulbs of a mutant of elephant garlic were investigated, and three new steroidal saponins named yayoisaponins A-C were obtained together with the known dioscin and aginoside. Their structures, including the relative stereochemistry, were elucidated by spectral data interpretation, while the absolute stereochemistry of the sugar moieties was assigned on the basis of a chiral gas chromatographic analysis of the acid hydrolysates. Yayoisaponins A-C and aginoside exhibited not only in vitro cytotoxicity against P388 cells at 2.1 μg/ml, but also antifungal activity against Mortierella ramanniana at 10 μg/disk.

  mutant, cytotoxicity, antifungal, elephant garlic, saponin

  NCBI PubMed ID: 9836426
  Publication DOI: 10.1271/bbb.62.1904
  Journal NLM ID: 9205717
  Publisher: Japan Society for Bioscience, Biotechnology, and Agrochemistry
  Correspondence: Fusetani N
  Institutions: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, Tokyo, Japan, Institute for Consumer Healthcare, Yamanouchi Pharmaceutical Co. Ltd., Tokyo, Japan
  Methods: 13C NMR, 1H NMR, IR, HPLC, extraction, optical rotation measurement, CC, HR-FAB-MS
  
   
  
  Allium ampeloprasum (Yayoi No. 1)
  CSDB ID 63549 (all data & tools)