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Structure type: monomer ; 491.3614
C₂₉H₄₉NO₅
Trivial name: holacurtine
Compound class: triterpenoid glycoside

• Article ID: 11551
  Kam T, Sim K, Koyano T, Toyoshima M, Hayashi M, Komiyama K "Cytotoxic and leishmanicidal aminoglycosteroids and aminosteroids from Holarrhena curtisii" - Journal of Natural Products 61(11) (1998) 1332-1336
  

  The EtOH extract of the leaves of Holarrhena curtisii yielded five new steroidal alkaloids: 17-epiholacurtine (3), 17-epi-N-demethylholacurtine (4), holacurtinol (5), 3α-amino-14β-hydroxypregnan-20-one (7), and 15α- hydroxyholamine (8), in addition to the known compounds, holacurtine (1), N- demethylholacurtine (2); and holamine (6). All eight compounds showed significant cytotoxic and leishmanicidal activities.

  Magnetic Resonance Spectroscopy, HL-60 cells, antiprotozoal agents, Holarrhena curtisii, leukemia P388

  NCBI PubMed ID: 9834146
  Publication DOI: 10.1021/np970545f
  Journal NLM ID: 7906882
  Publisher: American Society of Pharmacognosy
  Correspondence: Kam T
  Institutions: Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia, Temko Corporation, Nakano, Tokyo, Japan, Kitasato Institute, Minato-ku, Tokyo, Japan
  Methods: 13C NMR, 1H NMR, NOE, IR, extraction, optical rotation measurement, CC, HMBC, HMQC, COSY, HR-EI-MS
  
   
  
  Holarrhena curtisii
  CSDB ID 63410 (all data & tools)

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Structure type: monomer ; 477.3447
C₂₈H₄₇NO₅
Trivial name: N-demethyl-holacurtine
Compound class: triterpenoid glycoside

• Article ID: 11551
  Kam T, Sim K, Koyano T, Toyoshima M, Hayashi M, Komiyama K "Cytotoxic and leishmanicidal aminoglycosteroids and aminosteroids from Holarrhena curtisii" - Journal of Natural Products 61(11) (1998) 1332-1336
  

  The EtOH extract of the leaves of Holarrhena curtisii yielded five new steroidal alkaloids: 17-epiholacurtine (3), 17-epi-N-demethylholacurtine (4), holacurtinol (5), 3α-amino-14β-hydroxypregnan-20-one (7), and 15α- hydroxyholamine (8), in addition to the known compounds, holacurtine (1), N- demethylholacurtine (2); and holamine (6). All eight compounds showed significant cytotoxic and leishmanicidal activities.

  Magnetic Resonance Spectroscopy, HL-60 cells, antiprotozoal agents, Holarrhena curtisii, leukemia P388

  NCBI PubMed ID: 9834146
  Publication DOI: 10.1021/np970545f
  Journal NLM ID: 7906882
  Publisher: American Society of Pharmacognosy
  Correspondence: Kam T
  Institutions: Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia, Temko Corporation, Nakano, Tokyo, Japan, Kitasato Institute, Minato-ku, Tokyo, Japan
  Methods: 13C NMR, 1H NMR, NOE, IR, extraction, optical rotation measurement, CC, HMBC, HMQC, COSY, HR-EI-MS
  
   
  
  Holarrhena curtisii
  CSDB ID 63581 (all data & tools)