The whole plant of Ixeris denticulata f. pinnatipartita and I. sonchifolia respectively afforded a new guaianolide sesquiterpene lactone glucoside named ixerin X, 8β,15-dihydroxy-1(10),3,11(13)-guaiatriene-12, (1), ixerin Z, 1(10),3,11(13)-guaiatriene-12,6-olide-2-one-3-O-beta-D-glucopyranoside (2), whose structure and stereo-chemistry were determined by spectroscopic methods. 1 inhibited the growth of human breast cancer MCF7 and MDA468 cell lines.
cytotoxicity, compositae, guaianolide, ixerin Z, Ixeris denticulata f. pinnatipartita Kitag., I. sonchifolia Hance, sesquiterpene lactone glucoside, ixerin X
Publication DOI: 10.1016/S0928-3420(99)80052-4Journal NLM ID: 101589254Publisher: Toronto, ON: Canadian Center of Science and Education
Institutions: Shanghai Representative Office, Generation Health Co., Shanghai Medical University, 200032, Shanghai, China, Department of Pharmacognosy, China Pharmaceutical University, No 1 Shennong Rd. Nangjing, 210038, China, Toyama Medical & Pharmaceutical University, 230-01, Toyama, Japan
Methods: 13C NMR, 1H NMR, EI-MS, IR, FAB-MS, TLC, optical rotation measurement, cytotoxicity assay, HMBC, HMQC, COSY, NOESY, FT-IR
Found