Antisera generated against each of the nine known chemotypes of Salmonella lipopolysaccharide (LPS) core were characterized in order to delineate cross-reactive epitopes and define the bases for their accessibility. Strongly cross-reactive epitopes were associated with three chemotypes: Ra and Rb4, which recognized α-GlcNAc 1→2 αGlc, and Rd1, which recognized L-α-D-heptose-(1→7)-L-α-D-heptose. Both these disaccharides and the more weakly cross-reactive α-Gal-1→6-α-Glc terminal in Rb3 LPS represent branch points along the core oligosaccharide. Therefore, branch points in endotoxin core oligosaccharides may generally be cross-reactive.
Lipopolysaccharide, core, epitope, lipopolysaccharide core, epitopes, Salmonella, Salmonella lipopolysaccharide
NCBI PubMed ID: 9916124Journal NLM ID: 0246127Publisher: American Society for Microbiology
Correspondence: nnnalue@netscape.net
Institutions: Department of Medical Microbiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
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